Results 21 to 30 of about 894,684 (203)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

Preparation and Characterization of Liquid Fertilizers Produced by Anaerobic Fermentation

open access: yesAgriculture
Biol is a liquid product, obtained by anaerobic fermentation of local inputs, which improves the health of agroecosystems, which is an emerging area in agronomy.
Juan Francisco López-Rubio   +4 more
doaj   +1 more source

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

open access: yesArthritis Care &Research, Accepted Article.
Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang   +4 more
wiley   +1 more source

Comparative evaluation of liquid bio-inputs in compost-fertilized quinoa under inter-Andean valley conditions: beneficial microorganisms enhance yield and profitability

open access: yesFrontiers in Sustainable Food Systems
The study was conducted at the Canaán Agrarian Experimental Station (INIA, Ayacucho, Peru) during the 2024–2025 growing season to compare the effects of three liquid bio-inputs—beneficial microorganisms (BM), effective microorganisms (EM), and biol ...
Máximo Yupa-Quichua   +6 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Generación de energía renovable a partir del desarrollo de actividades pecuarias en el departamento de Madre de Dios

open access: yesCiencia Amazónica (Iquitos), 2014
La presente investigación tuvo como objetivo principal la generación de energía renovable aprovechando los residuos orgánicos de la actividad pecuaria del departamento de Madre de Dios, mediante la instalación de tecnologías para la generación de biogás ...
Vadick Fernández Romero   +2 more
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

open access: yesAdvanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang   +20 more
wiley   +1 more source

A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive–Compulsive Disorder

open access: yes, 2021
Neuromodulation: Technology at the Neural Interface, EarlyView.
Tim A. M. Bouwens van der Vlis   +1 more
wiley   +1 more source

Empleo de biol con desechos de pescado en el cultivo de Lactuca sativa en Huancavelica

open access: yesRevista de Investigación e Innovación Agropecuaria y de Recursos Naturales
Pampas, ubicado en Huancavelica - Perú, presenta un precario manejo de los desechos de pescado, donde cotidianamente son vertidos al suelo y ríos, exponiéndolos al aire libre; proponiendo la forma de manejo de dichos residuos, la presente investigación ...
Ingrid Polet Chávez-Merino   +5 more
doaj   +1 more source

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