Results 171 to 180 of about 310,970 (312)

Therapeutic Switching of Biological Drugs in Paediatric Severe Asthma: Experience of a Referral Centre. [PDF]

Biomedicines
Ferraro VA, Amadi M, Ferasin V, Zanconato S, Carraro S.   +4 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Biologic Therapy in Pregnant Women with Plaque Psoriasis: A Narrative Review of Maternal and Fetal Safety Considerations. [PDF]

Pharmaceuticals (Basel)
Nagendra S, Karampinis E.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Safety of Biologic Therapy for Inflammatory Bowel Disease in Liver Transplant Recipients. [PDF]

Biomedicines
Elger T, Loibl J, Müller M, Rusch S, Baier-Kleinhenz L, Kandulski A, Buechler C, Tews HC.   +7 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Patient Preferences in Hidradenitis Suppurativa Depend on Treatment Experience: Results from APProach-HS

Patient Preference and Adherence
Christian Kromer,1 Kristin Faverio,2,3 Tatiana Görig,4 Sylke Schneider-Burrus,5 Friderike Benzel,2 Matthias Goebeler,6 Dagmar Presser,6 Patrick Schummer,6 Marthe-Lisa Schaarschmidt,7 Wolfgang Harth,8 Rotraut Mössner,1,* Wiebke K Peitsch2,*
Kromer C, Faverio K, Görig T, Schneider-Burrus S, Benzel F, Goebeler M, Presser D, Schummer P, Schaarschmidt ML, Harth W, Mössner R, Peitsch WK   +11 more
doaj  

Disease Knowledge Assessed by RAKE-T and Its Sociodemographic and Clinical Correlates in Patients with Rheumatoid Arthritis Receiving Biologic and Targeted Synthetic DMARDs: A Multicenter Cross-Sectional Study. [PDF]

J Clin Med
Lermi N, Garip E, İstanbullu AY, Akyüz L, Us Demirelli B, Albayrak F, Yağız B, Tezcan ME, Dalkılıç E, Pehlivan Y, Coşkun BN.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source