Results 61 to 70 of about 302,285 (314)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles

Journal of Extracellular Biology
While extracellular vesicles (EVs) are increasingly recognized for their diagnostic and therapeutic potential, many unknowns remain. An emerging and important concept in EV biology is the EV biomolecular corona, a dynamic layer of absorbed biomolecules ...
Frederic St‐Denis‐Bissonnette, Hala Halabi, Marybeth Creskey, Melanie Kirkby, Xu Zhang, Dylan Burger, Lisheng Wang, Jessie R. Lavoie   +7 more
doaj   +1 more source

The effect of light-gray forest soil tilling systems on the yield and quality of oat grain in the Nizhny Novgorod region

Аграрная наука Евро-Северо-Востока, 2020
The research was conducted in the Nizhny Novgorod region in 2019 on light gray forest soil in the pea-oat crop rotation link. Studied was the effect of soil tillage systems (traditional mouldboard tillage with mouldboard plow; non- mouldboard "deep ...
A. V. Ivenin, A. P. Sakov
doaj   +1 more source

Biological assays with special reference to biological standards [PDF]

Journal of Hygiene, 1950
A paper on biological assays and biological standards might be expected to start with a definition. What is a biological assay and what is a biological standard? However, I shall for the moment make the somewhat doubtful assumption that we all know the answer to those questions but shall return to them later, making a start meanwhile by discussing some
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Influence of biologic and conventional disease-modifying antirheumatic drugs on COVID-19 incidence among rheumatic patients during the first and second wave of the pandemic in Iran

, 2022
INTRODUCTION: During the SARS-CoV-2 virus pandemic, immunosuppressive agents in treating chronic disease have become a concern, and rheumatic patients are not an exception.
Mirfeizi, Zahra, Firoozabadi, Mona, Zhaleh Shariati-Sarabi, Shariati-Sarabi, Zhaleh, Zahra Mirfeizi, Dadgar Moghadam, Malihe, Hashemzadeh, Kamila, Malihe Dadgar Moghadam, Sahebari, Maryam, Kamila Hashemzadeh, Mona Firoozabadi, Maryam Sahebari   +11 more
core   +1 more source

Biological information specialists for biological informatics.

Journal of biomedical discovery and collaboration, 2007
Data management and integration are complicated and ongoing problems that will require commitment of resources and expertise from the various biological science communities. Primary components of successful cross-scale integration are smooth information management and migration from one context to another.
Heidorn, P. Bryan, Palmer, Carole L., Wright, Daniel T.   +2 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

Frontiers in Immunology, 2017
Multiple sclerosis (MS) is an inflammatory demyelinating disease in which cytokines produced by immune cells that infiltrate the brain and spinal cord play a central role.
Jin Kyeong Choi, Ivy M. Dambuza, Chang He, Chang He, Cheng-Rong Yu, Anita N. Uche, Mary J. Mattapallil, Rachel R. Caspi, Charles E. Egwuagu   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source