Results 91 to 100 of about 8,290,554 (306)

BIOLOGICS IN DERMATOLOGIC THERAPY - AN UPDATE

Indian Journal of Dermatology, 2009
Biologics are protein molecules which are used in various diseases to target the specific points in the immunopathogenesis of the diseases. The molecules are produced by recombinant DNA technology. The molecules bind to the specific targets without interfering wtih rest of the pathogenetic pathways.
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease

Insights into Imaging
Objectives Altered body fat and muscle mass in Crohn’s disease (CD) have been linked to adverse disease course and outcomes. Prediction of treatment response or remission (RoR) of small bowel CD (SBCD) to biologic therapy remains challenging. We aimed to
Naomi S. Sakai, Andrew A. Plumb, Norin Ahmed, Kashfia Chowdhury, Yakup Kilic, Maira Hameed, Anisha Patel, Anisha Bhagwanani, Emma Helbren, Rachel Hyland, Gauraang Bhatnagar, Harbir Sidhu, Hannah Lambie, James M. Franklin, Maryam Mohsin, Elen Thomson, Darren Boone, Damian Tolan, Safi Rahman, Nik Ding, Gordon W. Moran, Stuart Bloom, Ailsa Hart, Alex Menys, Simon Travis, Steve Halligan, Stuart A. Taylor, On Behalf of the Motility trial investigators   +27 more
doaj   +1 more source

Risk Factors for Medication Nonadherence to Self-Injectable Biologic Therapy in Adult Patients With Inflammatory Bowel Disease.

Inflammatory Bowel Diseases, 2019
BACKGROUND In inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), nonadherence to biologic therapy increases risk of disease flare. The aim of this study was to identify risk factors for nonadherence.
Nisha B. Shah, J. Haydek, J. Slaughter, J. Ashton, Autumn D. Zuckerman, Rochelle Wong, F. Raffa, Ailish Garrett, Caroline Duley, K. Annis, Julianne H. Wagnon, L. Gaines, Robin L. Dalal, Elizabeth A. Scoville, D. Beaulieu, D. Schwartz, S. Horst   +16 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

29 | INNOVATIVE THERAPEUTIC STRATEGIES IN GENODERMATOSIS: AN ITALIAN MULTICENTRE STUDY

Dermatology Reports
Background. Genodermatoses are a group of rare inherited disorders affecting the skin and its adnexa. Their clinical presentation is heterogeneous, reflecting the wide underlying genetic heterogeneity.
Associazione Dermatologi-Venereologi Ospedalieri Italiani e della Sanità Pubblica
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Biologic therapy-induced pemphigus [PDF]

Anais Brasileiros de Dermatologia, 2017
Marina Zoega Hayashida, Jhonatan Rafael Siqueira Pinheiro, Milvia Maria Simões e Silva Enokihara, Mônica Ribeiro de Azevedo Vasconcellos   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source