Results 71 to 80 of about 8,290,554 (306)

Safety of Biologic Therapy in Older Patients with Immune-Mediated Diseases: A Systematic Review and Meta-Analysis

Clinical Gastroenterology and Hepatology, 2019
Background & Aims: Management of immune-mediated inflammatory diseases often requires lifelong immunosuppression. Increasing numbers of older patients have inflammatory diseases and are particularly vulnerable to risks of immune suppressive therapies ...
N. Borren, A. Ananthakrishnan
semanticscholar   +1 more source

Portuguese recommendations for the treatment of psoriasis with biologic therapy

EJD. European journal of dermatology, 2020
Psoriasis is a highly prevalent chronic, inflammatory multisystem disease with a considerable impact on patients’ quality of life and the healthcare system.
T. Torres, Rui Tavares Bello, M. J. Paiva Lopes, Francisco Menezes Brandão, A. Ferreira, P. Ferreira, P. Varela, Artur Sousa Basto, Marta Pereira, M. Selores, Gabriela Marques Pinto, Antonio Pinto Soares, P. Filipe   +12 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Antinuclear Antibodies Predict Treatment Escalation and Biologic Switching in Rheumatoid Arthritis

Diagnostics
Background: Antinuclear antibodies (ANAs) are frequently detected in patients with rheumatoid arthritis (RA); however, their prognostic relevance for predicting treatment escalation and biologic therapy initiation remains incompletely understood ...
Zeynel Abidin Akar, Dilan Yıldırım, Mehmet Çiftçi, Zeynep Işık Sula, Serap Karaman, Remzi Çevik, Mehmet Karakoç, Serda Em, İbrahim Batmaz, Pelin Oktayoğlu, Mehmet Çağlayan   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tacrolimus therapy for ulcerative colitis: a retrospective study of factors associated with inducing and maintaining remission

BMC Gastroenterology
Background Tacrolimus (TAC) is highly effective pharmacotherapy for refractory ulcerative colitis. However, the factors involved in achieving and maintaining remission are unclear, and the optimal maintenance therapy after inducing remission with TAC ...
Ayumi Ito, Shun Murasugi, Miki Koroku, Maria Yonezawa, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige, Yousuke Nakai   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cost-effectiveness and comparative effectiveness of biologic therapy for asthma: To biologic or not to biologic?

Annals of Allergy, Asthma & Immunology, 2019
OBJECTIVE To evaluate relevant studies and documents that address the cost-effectiveness and comparative effectiveness of biologics current approved by the US Food and Drug Administration for the treatment of asthma. DATA SOURCES Publications currently
W. Anderson, S. Szefler
semanticscholar   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source