Results 151 to 160 of about 3,532,181 (218)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predictive modeling in biology and medicine: Digital twins and multi-scale modeling. [PDF]

PLoS Comput Biol
Alber M, Smith A, Laubenbacher R, Merks RMH.   +3 more
europepmc   +1 more source

Toward next-generation hip implants: From failure mechanisms to translational design. [PDF]

J Orthop Translat
Luo Y, Turgeon T, Polyzois I.
europepmc   +1 more source

Functional Interpretation of Recurrent Genetic Variants in Hepatocellular Carcinoma: Molecular Consequences and Clinical Relevance. [PDF]

Hum Mutat
Ye Y, Xu Z, Wang J, Chen C, Peng Y, Li B.   +5 more
europepmc   +1 more source

A unified voice for evidence-based psychiatry: a global response to the WHO guidance on ECT. [PDF]

Eur Arch Psychiatry Clin Neurosci
Sartorius A, Zilles-Wegner D.
europepmc   +1 more source

Antioxidant and antibacterial properties of transition metals and metal oxides for medical uses: mechanisms, design strategies, and biomedical perspectives. [PDF]

Nanoscale Adv
Mohammed Ali IA, Ben Ahmed A.
europepmc   +1 more source