Results 251 to 260 of about 7,643,336 (318)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Phytochemical Constituents and Biological Activities of <i>Ononis spinosa</i>: A Comprehensive Review. [PDF]

Plants (Basel)
Nechita VI, Tărău AP, Şuster AI, Nechita MA, Toiu A, Benedec D, Hanganu D, Siserman C, Drugan C, Oniga I.   +9 more
europepmc   +1 more source

Solvent-Dependent Biological Activities of Aqueous and Ethanolic Extracts From Edible Insect Larvae. [PDF]

Food Sci Nutr
Kang MC, Im ST, Kim TK, Park MK, In Yong H, Ahn G, Han EJ, Cha JY, Song KM, Choi YS.   +9 more
europepmc   +1 more source

Coumarin hybrids as privileged therapeutic scaffolds: biological activities, mechanistic insights, and therapeutic potential. [PDF]

RSC Adv
Naeem N, Shakoor B, Sadiq A, Al Nami SY, Hossan A, Mughal EU.   +5 more
europepmc   +1 more source

<i>Glechoma hederacea</i> (L.): Phytochemical Profile, Biological Activities and Emerging Perspectives in Oral Health-A Review. [PDF]

Plants (Basel)
Bereteu-Costa AD, Pallag A, Potra Cicalău GI, Ganea M, Pașca MB, Morar MT, Ciavoi G.   +6 more
europepmc   +1 more source

Recent advances in <i>Siraitia grosvenorii</i> polysaccharides: Extraction, structural characteristics, biological activities and structure-activity relationships. [PDF]

Food Chem X
Luan Y, Zhu S, Yin F, Yan G, Gao J, Huang F, Guo J, Wang C, Ren Y, Zhang N, Sun H.   +10 more
europepmc   +1 more source

Imidazo[1,2‑<i>a</i>]pyridines as Privileged Scaffolds: Synthetic Advances, Biological Activities, and Translational Challenges. [PDF]

ACS Omega
Antoniolli G, Chaguri R, Grabauskas LA, Arruda DC, Rodrigues T.   +4 more
europepmc   +1 more source

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ECVAM's Activities on Biologicals

Alternatives to Laboratory Animals, 2002
This paper summarises key activities initiated and the progress achieved between April 1993 and June 2002 in implementing the Three Rs in one of ECVAM's priority areas — the production and quality control of biologicals. These have included: organising nine key workshops; financially supporting and/or participating in a number of prevalidation and/or ...
Halder, M, Balls, M, Hendriksen, C, Cussler, K   +3 more
openaire   +3 more sources