Results 91 to 100 of about 10,259,014 (319)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1941

, 1942
Annual report of the Marine Biological Laboratory in Woods Hole. 1941.
Marine Biological Laboratory (Woods Hole MA)
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1980

, 1981
Annual report of the Marine Biological Laboratory in Woods Hole. 1980.
Marine Biological Laboratory (Woods Hole MA)
core  

Quassinoids and Their Biological Activity

Natural Product Communications, 2007
Ailanthus is an important genus of the Simaroubaceae family that is widely distributed in Asia and north Australia, and which is used in folk medicines. The plants of this genus have numerous therapeutic applications and have, therefore, been the subject
Bipin Chandra Joshi, Ram Prakash Sharma, Anakshi Khare   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1939

, 1940
Annual report of the Marine Biological Laboratory in Woods Hole. 1939.
Marine Biological Laboratory (Woods Hole MA)
core  

Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis

Digital Chinese Medicine
Objective: To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts. Methods: The total phenolic, flavonoid, flavonol,
Fekhikher Zohra, Benariba Nabila, Radia Brixi Gormat, Hassain Reda, Abdelli Imen, Z. Sekkal Fatima, Kachekouche Youssouf, Taibi Warda, Brikci Sohayb Bekkal, Terki Mohammed, Benramdane Hanane, Adjdir Sara   +11 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1984

, 1985
Annual report of the Marine Biological Laboratory in Woods Hole. 1984.
Marine Biological Laboratory (Woods Hole MA)
core