Results 101 to 110 of about 4,765,787 (310)
(Re)conceptualising physical activity participation as career [PDF]
, 2019 Physical activity is increasingly positioned as playing an important role in preventing and mitigating many of the decrements associated with biological ageing.
Alexander +19 more
core +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Digital Chinese MedicineObjective: To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts. Methods: The total phenolic, flavonoid, flavonol,
Fekhikher Zohra +11 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Quassinoids and Their Biological Activity
Natural Product Communications, 2007 Ailanthus is an important genus of the Simaroubaceae family that is widely distributed in Asia and north Australia, and which is used in folk medicines. The plants of this genus have numerous therapeutic applications and have, therefore, been the subject
Bipin Chandra Joshi +2 more
doaj +1 more source
Research progress on functionof natural pigment astaxanthin
Liang you shipin ke-ji, 2019 Astaxanthin belongs to lutein in carotenoids and is a secondary metabolite synthesized by many microalgae, yeasts and bacteria. Astaxanthin has been listed as one of the best preventive and therapeutic agent for many acute or chronic diseases due to its ...
MENG Ang +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Functional and applied significance of biological activity of soil
Біологічні студії, 2013 This article provides an overview of scientific information on functional and applied value of soil biological activity and soil processes. Soil is a dynamic alive creation, plant productivity, environmental quality, balance and function of the biosphere
M. Z. Mekich, N. M. Dzhura, O. I. Terek
doaj +1 more source