Results 101 to 110 of about 16,493,208 (361)

Activity-Guided Design of HDAC11-Specific Inhibitors [PDF]

, 2019
Mammalian histone deacetylases (HDACs) are a class of enzymes that play important roles in biological pathways. Existing HDAC inhibitors target multiple HDACs without much selectivity.
Ji Cao (237887), Cheng-Liang Zhu, Hening Lin, Seth P. Miller (2919296), Hening Lin (1306563), Se In Son, Se In Son (6904298), Cheng-Liang Zhu (1336629), Ji Cao, Seth P. Miller   +9 more
core   +1 more source

BIOLOGICALLY ACTIVE OXADIAZOLE

Journal of Drug Delivery and Therapeutics, 2015
As we know that, Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring and is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen (-N=) [1,2]. There are three known isomers that is 1,2,4-oxadiazole, 1,2,3-oxadiazole and 1,2,5-oxadiazole (Figure 1.0 ...
Chhama Shukla, Sanchit Srivastav
openaire   +2 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Progress in biological chirality / [PDF]

, 2004
Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality.
Interdisciplinary Symposium on Biological Chirality(3rd :2003 :Modena, Italy), Pályi, G.(Gyula),, Zucchi, C.(Claudia),, Caglioti, Luciano.   +3 more
core  

Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor [PDF]

, 2014
Progesterone receptor (PR) exists in two isoforms, PRA and PRB, and both contain activation functions AF-1 and AF-2. It is believed that AF-1 is primarily responsible for the ligand-independent activity, whereas AF-2 mediates ligand-dependent PR ...
Sim, Kae Hwan, Dong, Xue Ming, Sze, Siu Kwan, Sun, Yang, Woo, Amanda Rui En, Lin, Valerie Chun-Ling, Chung, Hwa Hwa   +6 more
core   +1 more source

Integrated DFT, DOS, and molecular docking study of oxazine derivatives as promising scaffolds for Anti-HMPV drug design

Chemical Physics Impact
Oxazine derivatives 1–3 was investigated through density functional theory (DFT at B3LYP/6–311 G basis set, time-dependent DFT (TD-DFT) in this study and the molecular Hirshfeld surface analysis (HSA), molecular electrostatic potential (MEP) mapping, and
Rania Omrani, Imen Kharmachi, Mohamed Amine Ben Abdallah, Chiraz Labassi, Sonia Taktouk   +4 more
doaj   +1 more source

Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties

Molecules, 2017
Essential oils of oregano are widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Nevertheless, recent investigations have demonstrated that these compounds are also potent antioxidant, anti ...
N. Leyva-López, E. P. Gutiérrez-Grijalva, Gabriela Vazquez-Olivo, J. B. Heredia   +3 more
semanticscholar   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Isolation, characterization and biological activity of naphthoquinones from Calceolaria andina L. [PDF]

, 1999
Two compounds recognized as responsible for the insecticidal activity of extracts of Calceolaria andina L. (Scrophulariaceae) have been isolated and characterized as 2-(1,1-dimethylprop-2-enyl)3-hydroxy-1,4-naphthoquinone and the corresponding acetate, 2-
Denholm, I., Batty, D., Batty, Duncan, Simmonds, M. S. J., Denholm, Ian, Mead-Briggs, M., Vinall, Stephen, Khambay, B. P. S., Niemeyer, H. M., Cahill, M., Mead-Briggs, Mike, Vinall, S., Niemeyer, Hermann M., Simmonds, Monique S.J., Khambay, Bhupinder P.S., Cahill, Matthew   +15 more
core   +1 more source