Results 141 to 150 of about 16,493,208 (361)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evaluation of the biological activity of novel monocationic fluoroaryl-2,2’-bichalcophenes and their analogues [PDF]

, 2014
Warda A Hussin,1,2,*,† Mohamed A Ismail,1,3,* Abdullah M Alzahrani,1 Wael M El-Sayed,1,4 1King Faisal University, College of Science, Departments of Chemistry and Biological Sciences, Hofuf, Saudi Arabia; 2Al-Azhr University, Faculty of ...
Ismail MA, Hussin WA, Alzahrani AM, El-Sayed WM   +3 more
core  

Event-related alpha suppression in response to facial motion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.While biological motion refers to both face and body movements, little is known about the visual perception of facial motion. We therefore examined alpha wave suppression
Michael J. Wright (524298), Spencer Janine V., Christine Girges, Girges, C, Michael J Wright, Janine V. Spencer (524299), Wright, MJ, Spencer, JV, O'Brien, JMD, O’Brien Justin M. D., O'Brien, J, Janine V Spencer, Justin M. D. O’Brien (524300), Girges Christine, Justin M D O'Brien, Spencer, J, Christine Girges (524297), Wright, M, O’Brien, JMD, Wright Michael J.   +19 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus comatus [PDF]

, 2012
Background: Although many physiological functions of Coprinus comatus have been reported, there has been no report on the antinociceptive activity of Coprinus comatus.
Ren, Jun, Shi, Jin-Li, Han, Chun-Chao, Liu, Zhen-Quan, Guo, Jian-You, Guo, JY (reprint author), Zhejiang Normal Univ, Dept Psychol, Jinhua 321004, Peoples R China.   +5 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Organic Compounds with Biological Activity

Compounds
The Special Issue with the title ‘Organic Compounds with Biological Activity’ [...]
Małgorzata Anna Marć, Enrique Domínguez-Álvarez   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis

Digital Chinese Medicine
Objective: To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts. Methods: The total phenolic, flavonoid, flavonol,
Fekhikher Zohra, Benariba Nabila, Radia Brixi Gormat, Hassain Reda, Abdelli Imen, Z. Sekkal Fatima, Kachekouche Youssouf, Taibi Warda, Brikci Sohayb Bekkal, Terki Mohammed, Benramdane Hanane, Adjdir Sara   +11 more
doaj   +1 more source