Results 161 to 170 of about 4,765,787 (310)

Molecular identification and biological activity of a red sea bacterial isolate. [PDF]

BMC Microbiol
Matar MM, Elkholy YN, Negm WA, Elfeky HH, Yassien MA.   +4 more
europepmc   +1 more source

Main results of the experiments conducted during the flight of the Kosmos-1129 Biosatellite and the status of preparation of studies on the next biosatllite [PDF]

Experiments included studies on the biological effects of weightlessness. Space flight stress, disorientation, and physiological factors are discussed for each experimental subject. The subjects included rats, drosophila flies, and plants.
Ilin, E. A.
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ferrocenoylation of Uracil Derivatives: Study of Reaction Regioselectivity and Biological Activity. [PDF]

Molecules
Lapić J, Kuzman I, Frkanec R, Frkanec L, Djaković S.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Evaluation of biological activity via biospeckle laser imaging. [PDF]

Biophys Rep
Ansari MZ.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Studying the Biological Activity of Cerium Dioxide Nanoparticles Using Bacterial Biosensors. [PDF]

Int J Mol Sci
Silina EV, Prazdnova EV, Emelyantsev SA, Khmelevtsova LE, Statsenko VN, Manturova NE, Palkina KA, Yampolsky IV, Stupin VA.   +8 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Editorial: Adipose tissue and skeletal muscle as endocrine organs: Role of cytokines in health and disease

Frontiers in Physiology, 2022
Ana Claudia Garcia De Oliveira Duarte, Guilherme Fleury Speretta, Ana Maria Teixeira, Fábio Santos Lira, Fábio Santos Lira   +4 more
doaj   +1 more source