Results 251 to 260 of about 16,187,582 (338)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Construction of Minigenome Replicon of Nipah Virus and Investigation of Biological Activity. [PDF]

Viruses
Wang F, Chen R, Zhong J, Zhou A, Peng R, Xue B, Zhou Y, Tang J, Chen X, Yang Q.   +9 more
europepmc   +1 more source

CYTOKININS: SYNTHESIS OF 6-(3-METHYL-3-BUTENYLAMINO)-9-β-D-RIBOFURANOSYLPURINE (3IPA), AND THE EFFECT OF SIDE-CHAIN UNSATURATION ON THE BIOLOGICAL ACTIVITY OF ISOPENTYLAMINOPURINES AND THEIR RIBOSIDES

, 1968
Nelson J. Leonard, Sidney M. Hecht, Folke Skoog, Ruth Y. Schmitz   +3 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Biological activity of vanadium compounds

Open Life Sciences, 2006
Goc Anna
doaj   +1 more source

Expression and Biological Activity Analysis of Recombinant Fibronectin3 Protein in <i>Bacillus subtilis</i>. [PDF]

BioTech (Basel)
Lu C, Xu G, Tian Y, Yi Z, Tang X.
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Synthesis and Biological Activity of Ultrashort Antimicrobial Peptides Bearing a Non-Coded Amino Acid. [PDF]

J Pept Sci
Peggion C, Schivo A, Rotondo M, Oancea S, Popovici LF, Călin T, Mkrtchyan A, Saghyan A, Hayriyan L, Khachatryan E, Formaggio F, Biondi B.   +11 more
europepmc   +1 more source

FRACTIONATION OF HABU SNAKE VENOM BY CHROMATOGRAPHY ON CM-CELLULOSE WITH SPECIAL REFERENCE TO BIOLOGICAL ACTIVITIES

, 1960
Akira Ohsaka
openalex   +2 more sources

The biological activity of pure peptides obtained by enzymic hydrolysis of insulin [PDF]

, 1960
Davidson Nicol
openalex   +1 more source