Results 281 to 290 of about 16,621,712 (406)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Protolytic properties and biological activity of spinorphin and its butyric acid derivatives in aqueous solution. [PDF]

Amino Acids
Pająk M, Kamysz E, Banach M, Jankowski WM, Tarasiuk-Zawadzka A, Fichna J, Woźniczka M.   +6 more
europepmc   +1 more source

Optimization of Flavonoid Extraction from Abelmoschus manihot Flowers Using Ultrasonic Techniques: Predictive Modeling through Response Surface Methodology and Deep Neural Network and Biological Activity Assessment [PDF]

Zenghong Sun, Wenhui Liu, Sha Zhang, Shuge Tian, Ainiwaer Aikemu   +4 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Phytosterols: Extraction Methods, Analytical Techniques, and Biological Activity. [PDF]

Molecules
Yoon BH, Truong VL, Jeong WS.
europepmc   +1 more source

Age-related biological activity of South American rattlesnake (Crotalus durissus terrificus) venom

, 2003
Maria F. Furtado, María Cristina dos Santos, Aura S. Kamiguti   +2 more
openalex   +1 more source

Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation

Electromagnetic Biology and Medicine, 2016
I. Yakymenko, O. Tsybulin, E. Sidorik, D. Henshel, O. Kyrylenko, S. Kyrylenko   +5 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Total Synthesis of (+)-Penicyclone A and Evaluation of Biological Activity Including Intermediate Compounds. [PDF]

Int J Mol Sci
Duvnjak M, Talajić G, Baranašić J, Baus Topić N, Čipčić Paljetak H, Cindro N.   +5 more
europepmc   +1 more source