Results 281 to 290 of about 16,187,582 (338)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Influence of solvents on the extraction efficiency and biological activity of marbled eel mucus. [PDF]

AMB Express
Huyen KT, Linh NQ.
europepmc   +1 more source

Biological Activities of Chlormadinone Acetate (II) Effects on the Rat Pregnancy, Fetal Development and Parturition

, 1966
TAMOTSU MIYAKE, Fumihiko Kobayashi, Kikuzo HORIBE, Hisato KAKUSHI, Katsumi Hara   +4 more
openalex   +2 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Research Progress on the Isolation, Purification, Structural Characteristics and Biological Activity Mechanism of <i>Pleurotus citrinopileatus</i> Polysaccharides. [PDF]

Molecules
Liu Z, Wang H.
europepmc   +1 more source

Studies on the High Molecular Weight Parotin-like Substance in Human Saliva. II. : Biological Activity

, 1969
Hiroshi Ueki
openalex   +2 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

PHOTOREGULATION OF BIOLOGICAL ACTIVITY BY PHOTOCHROMIC REAGENTS, III. PHOTOREGULATION OF BIOELECTRICITY BY ACETYLCHOLINE RECEPTOR INHIBITORS

, 1969
Walter J. Deal, Bernard F. Erlanger, David Nachmansohn   +2 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Preparation of a solid dispersion of Euptox A and evaluation of its biological activity and safety. [PDF]

PLoS One
Li H, Zhao R, Zhou W, Li Z, Chen W.
europepmc   +1 more source