Results 41 to 50 of about 4,765,787 (310)

Design, computational studies, Hirshfeld surface and In-Silico approach of novel pyrazoles and pyrazolines derivatives as promising antidiabetic agents

Scientific African
Novel pyrazole 3a-d, g and pyrazolines derivatives 3e-f were synthesized through nitrile imine-mediated tetrazolene cycloaddition (NITEC) reaction and the reasonable mechanism of the NITEC reaction was discussed using Density Functional Theory (DFT) at ...
Mohamed Amine Ben Abdallah, Rania Omrani, Chiraz Labassi, Sonia Taktouk, Jean-Luc Fillaut, Rafik Gatri   +5 more
doaj   +1 more source

Initial soil structural development under different types of vegetation [PDF]

, 2010
In September 2007, undisturbed soil cores were taken from experimental fields in The Netherlands and in Northern Sweden that had been under different types of vegetation during four years.
Cammeraat, E.L.H., Elgersma, A., Gustavsson, A.M.   +2 more
core   +1 more source

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]

, 2015
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo, Fumagallo, Felipe, Gillespie, David A., Gong, Eun Yeung, Morrice, Nicholas, Piscitello, Desiree, Smits, Veronique A.J.   +6 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Olive Residues as a Source of Bioactive Compounds

Chemistry Proceedings
The production of olive oils implies the generation of high quantities of solid residues and/or wastewater that may have a great impact on terrestrial and aquatic environments because of their phytotoxicity.
Carlos Alvarez, Margarita Gutierrez
doaj   +1 more source

Biological activity in the wake of an island close to a coastal upwelling [PDF]

, 2008
Hydrodynamic forcing plays an important role in shaping the dynamics of marine organisms, in particular of plankton. In this work we study the planktonic biological activity in the wake of an island which is close to an upwelling region.
Feudel, U., Hernandez-Garcia, E., Lopez, C., Sandulescu, M.   +3 more
core   +2 more sources

BIOLOGICAL ACTIVITIES OF LEUPEPTINS

The Journal of Antibiotics, 1969
Leupeptins, leupeptin Pr and leupeptin Ac, strongly inhibit proteolysis by plasmin, trypsin and papain, but do not inhibit proteolysis by α-chymotrypsin. The inhibition is competitive with substrates. The inhibitory effect on esterolysis by plasmin and trypsin is weaker than on proteolysis.
TAKAAKI AOYAGI, SETSUKO MIYATA, MASAKO NANBO, FUKIKO KOJIMA, MEIKI MATSUZAKI, MASAAKI ISHIZUKA, TOMIO TAKEUCHI, HAMAO UMEZAWA   +7 more
openaire   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Biological markers of disease activity in inflammatory bowel diseases

Gastroenterology Review, 2023
Inflammatory bowel diseases (IBD) are chronic intestinal conditions of multifactorial aetiology including genetic susceptibility, immunological impairment, dysbiosis, and environmental factors.
Edyta Szymanska, Sylwia Szymanska, Maciej Dadalski, Jaroslaw Kierkus   +3 more
doaj   +1 more source

Associations between selected demographic, biological, school environmental and physical education based correlates, and adolescent physical activity

, 2011
The study investigated associations between selected physical activity correlates among 299 adolescents (90 boys, age 12-14 years) from 3 English schools. Physical activity was assessed by self-report and accelerometry. Correlates represented biological,
Fairclough, Stuart J., Hilland, Toni A., Ridgers, Nicola D., Stratton, Gareth   +3 more
core   +1 more source