Results 21 to 30 of about 8,263,078 (268)

Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline [PDF]

Kemija u Industriji, 2014
The derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopeful that some of the compounds of this group will develop into new efficient drugs for different types of diseases in the future.
Sović, I., Karminski-Zamola, G.
doaj   +1 more source

lncRNA LINC00152 knockdown suppressed hepatic cancer biological activity

Archives of Medical Science, 2020
Introduction Hepatic cancer is one of the most lethal cancers and has a poor prognosis. The purpose of this study was to evaluate whether lncRNA LINC 00152 had effects on the development of hepatic cancer and the related mechanisms.
Yajun Ma, Xuli Yang, Yong Xu, Rongping Zhou, Gang Chen, Deseng Fan, Shikun Luo, Zhili Shen, Dong Yang   +8 more
doaj   +1 more source

Intensity Trajectories During High-Intensity Interval Training and Their Impact on Health Outcomes in Adolescents: Evidence from School-Based PE Settings (Peer-Heart Studies)

Life
Background: High-intensity interval training (HIIT) is increasingly implemented in school-based physical education, yet little is known about how exercise intensity changes across repeated sessions and whether such trajectories are associated with ...
Jarosław Domaradzki, Dawid Koźlenia
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Diurnal variation in physical activity and musculoskeletal injury risk across sex and habitual exercise timing among physically active students

Scientific Reports
This study examined whether habitual exercise timing and sex are associated with lower-limb injury prevalence and frequency in physically active young adults.
Jarosław Domaradzki, Dawid Koźlenia
doaj   +1 more source

Dietary supplement use and knowledge among athletes: prevalence, compliance with AIS classification, and awareness of certification programs

Journal of the International Society of Sports Nutrition
Background The use of dietary supplements is widespread among athletes, with intake influenced by factors such as sport-discipline, competitive level, and gender.
Anna Broniecka, Aleksandra Sarachman, Aleksandra Zagrodna, Anna Książek   +3 more
doaj   +1 more source

N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2-enoyl]phenyl}quinoline-3-carboxamide

Molbank, 2017
An amide chalconehas been synthesized in a two-step reaction. First, N-(4-acetylphenyl)quinoline-3-carboxamide 2 was synthesized by the reaction of quinoline-3-carboxylic acid 1 and thionyl chloride (SOCl2), following the addition of 4-aminoacetophenone.
Efrain Polo, Jorge Trilleras, Margarita Gutiérrez Cabrera   +2 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Synthesis and In-Silico Analysis of Novel Tetrahydroquinolines and Their Antioxidant Activity

Chemistry Proceedings
Within the area of study of neurodegenerative diseases, particularly Alzheimer’s disease (AD), this research focused on the synthesis and evaluation of novel tetrahydroquinoline (THQ) derivatives with potential antioxidant activity.
Cristóbal Dinamarca, Mercedes Pinochet, Margarita Gutierrez   +2 more
doaj   +1 more source