Results 21 to 30 of about 4,765,787 (310)

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh, Ausar, Salvador F, Brookes, Roger H, Dockrell, Hazel M, Ha, Yukyung, Hakimi, Jalil, Hasija, Manvi, Rahman, Nausheen, Smith, Steven G, Todryk, Stephen M   +9 more
core   +1 more source

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Genome Medicine, 2017
Background Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone.
Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen   +7 more
doaj   +1 more source

Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline [PDF]

Kemija u Industriji, 2014
The derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopeful that some of the compounds of this group will develop into new efficient drugs for different types of diseases in the future.
Sović, I., Karminski-Zamola, G.
doaj   +1 more source

Providing the basis for a patient-centred and effective screening for cancer-related fatigue (MERLIN study): design of a longitudinal observational study

BMJ Open, 2023
Introduction Cancer-related fatigue (CRF) is a frequent and burdensome sequela of cancer and cancer therapies. It can persist from months to years and has a substantial impact on patients’ quality of life and functioning.
Martina E Schmidt, Karen Steindorf, Bernhard Holzner, Patricia Blickle, Alexander Haussmann, Anne Katrin Berger   +5 more
doaj   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Roadmap on semiconductor-cell biointerfaces. [PDF]

, 2018
This roadmap outlines the role semiconductor-based materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of next-generation electronic, optoelectronic, and mechanical devices ...
Anikeeva, Polina, Bao, Zhenan, Benfenati, Fabio, Bezanilla, Francisco, Cao, Yuhong, Carvalho-de-Souza, João L, Cestellos-Blanco, Stefano, Cifra, Michal, Galli, Giulia, Gorodetsky, Alon A, Gygi, Francois, Havelka, Daniel, Hjort, Martin, Jiang, Yuanwen, Kautz, Rylan, Kim, Samuel S, Krivosudský, Ondrej, Lanzani, Guglielmo, Liu, Jia, Lu, Timothy K, Melosh, Nicholas, Rogers, John A, Tian, Bozhi, Xu, Shuai, Yang, Peidong   +24 more
core   +1 more source

BIOLOGICAL ACTIVITY OF SUCCINIC ACIDS [PDF]

Biotechnologia Acta, 2018
The aim of the research was to detect the biological activity of aqueous solutions of various samples of amber from the Trancedniestria province, and to characterize their effect on the physiological processes of higher plants.
N. Ya. Levchyck, A. V. Liubinska, N. V. Skrypchenko, O. I. Dziuba, N. M. Kachalova, O. L. Mironov   +5 more
doaj   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source

Surface mixing and biological activity in the four Eastern Boundary Upwelling Systems [PDF]

, 2009
Eastern Boundary Upwelling Systems (EBUS) are characterized by a high productivity of plankton associated with large commercial fisheries, thus playing key biological and socio-economical roles.
Garcon, V., Hernandez-Garcia, E., Lopez, C., Morel, Y., Rossi, V., Sudre, J.   +5 more
core   +6 more sources

Biological Activity of Hexaazaisowurtzitane Derivatives

Molecules, 2023
Biologically active compounds of natural or synthetic origin have a complex structure and generally contain various structural groups among which polycyclic cage amines are found.
Daria A. Kulagina, Sergey V. Sysolyatin, Svetlana G. Krylova, Elena A. Kiseleva, Tatiana N. Povetyeva, Elena P. Zueva, Valeria V. Eremina, Natalia A. Alekseeva, Svetlana V. Strokova, Nikolai I. Suslov, Vadim V. Zhdanov   +10 more
doaj   +1 more source