Results 161 to 170 of about 3,406,662 (333)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Biological ageing and kidney transplantation
, 2022 The aim of this thesis was to investigate the impact of biological ageing in patients with chronic kidney disease, the effect of kidney transplantation on biological ageing and longterm outcome in patients with kidney failure.
Helen Erlandsson (18680722)
core
Menopause and ageing in women with multiple sclerosis
Frontiers in NeurologyBackgroundThe multiple sclerosis (MS) population is ageing, and a substantial proportion of women with MS are now peri- or postmenopausal. Whether menopause independently influences disease activity and progression remains unclear, and findings across ...
Cecilia Smith Simonsen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Vanhenemista säätelevät läpi elämän sekä perintö- että ympäristötekijät, kuten muokattavissa olevat elintapoihin liittyvät tekijät. DNA:n metylaatioon perustuvat estimaattorit, mukaan lukien "epigeneettiset kellot", ovat lupaavia biologisen ...
Kankaanpää, Anna
core +1 more source
Asia in the ageing century: part III - healthcare [PDF]
, 2013 With total health spending in the region worth over a trillion dollars in 2010 and demand for healthcare continuing to grow, Asian governments will have a tremendous challenge meeting and funding this demand.Summary• This is the third research brief in a
Rafal Chomik
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source