Results 201 to 210 of about 3,406,662 (333)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Blame the parents? The association between parental longevity and successful ageing [PDF]

Research has suggested that children of long-lived parents might age more successfully than children of short-lived parents. The aim of this study is to contribute further to the understanding of the association between parental longevity and offspring’s
Paola Zaninotto, Edlira Gjonça
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy. [PDF]

Osteoarthr Cartil Open
van der Kraan PM.
europepmc   +1 more source

Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states. [PDF]

Saudi J Biol Sci, 2022
Al-Daghri NM, Sabico S, Ansari MGA, Abdi S, Tripathi G, Chrousos GP, McTernan PG.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Development of Age- and Sex-Specific Metabolomics-Based Biological Ageing Clocks for 10-Year Mortality Prediction. [PDF]

Adv Sci (Weinh)
Peng L, Xie R, Holleczek B, Brenner H, Schöttker B.   +4 more
europepmc   +1 more source

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. [PDF]

Geroscience, 2022
Milicic L, Vacher M, Porter T, Doré V, Burnham SC, Bourgeat P, Shishegar R, Doecke J, Armstrong NJ, Tankard R, Maruff P, Masters CL, Rowe CC, Villemagne VL, Laws SM, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Australian Imaging Biomarkers and Lifestyle (AIBL) Study.   +16 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex. [PDF]

J Sleep Res
Valverde-Perez E, Almeida MB, Sacramento JF, Olea E, Prieto-Lloret J, Rocher A, Conde SV.   +6 more
europepmc   +1 more source