Results 31 to 40 of about 3,406,662 (333)

Effect of Photofunctionalization with 6 W or 85 W UVC on the Degree of Wettability of RBM Titanium in Relation to the Irradiation Time

Applied Sciences, 2021
Photoactivation with ultraviolet C light can reverse the effects derived from biological ageing by restoring a hydrophilic surface. Ten titanium discs were randomly divided into three groups: a control group, a 6 W group, and an 85 W group.
Arturo Sanchez-Perez, Nuria Cano-Millá, María José Moya Villaescusa, José María Montoya Carralero, Carlos Navarro Cuellar   +4 more
doaj   +1 more source

FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity

Frontiers in Cell and Developmental Biology, 2021
Proteostasis collapses during aging resulting, among other things, in the accumulation of damaged and aggregated proteins. The proteasome is the main cellular proteolytic system and plays a fundamental role in the maintenance of protein homeostasis.
Marianna Kapetanou, Tobias Nespital, Luke S. Tain, Andre Pahl, Linda Partridge, Efstathios S. Gonos   +5 more
doaj   +1 more source

Frailty and Biological Age [PDF]

Annals of Geriatric Medicine and Research, 2021
A reliable model of biological age is instrumental in the field of geriatrics and gerontology. This model should account for the heterogeneity and plasticity of aging and also accurately predict aging-related adverse outcomes. Epigenetic age models are based on DNA methylation levels at selected genomic sites and can be significant predictors of ...
Lixin Ji, S. Michal Jazwinski, Sangkyu Kim   +2 more
openaire   +3 more sources

Generation of induced pluripotent stem cell line (TMOi001-A-11) carrying a homozygous deletion in the synemin gene using CRISPR/Cas9

Stem Cell Research, 2023
A number of genetic variants in the SYNM gene encoding for the intermediate filament synemin have been reported in patients with cardiomyopathies, skeletal myopathies, cancer and certain neurodegenerative disorders.
Caterina Gargano, Jean-Sébastien Vartanian-Grimaldi, Yeranuhi Hovhannisyan, Pierre Joanne, Onnik Agbulut, Zhenlin Li, Ara Parlakian, Jean-François Decaux   +7 more
doaj   +1 more source

Seasonal variation in telomerase activity and telomere dynamics in a hibernating rodent, the garden dormouse (Eliomys quercinus)

Frontiers in Physiology, 2023
Telomere dynamics in hibernating species are known to reflect seasonal changes in somatic maintenance. Throughout hibernation, the periodic states of rewarming, known as inter-bout euthermia or arousals, are associated with high metabolic costs including
Carlos Galindo-Lalana, Franz Hoelzl, Sandrine Zahn, Caroline Habold, Jessica S. Cornils, Sylvain Giroud, Sylvain Giroud, Steve Smith   +7 more
doaj   +1 more source

Biological Age Predictors [PDF]

EBioMedicine, 2017
The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate biomarkers that may be considered as biological age predictors.
Jylhävä, Juulia, Pedersen, Nancy L., Hägg, Sara   +2 more
openaire   +3 more sources

Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies.

The Lancet Healthy Longevity, 2023
BACKGROUND Rheumatoid arthritis is a chronic autoimmune disorder that affects life expectancy. Accelerated biological ageing is thought to be a major risk factor for age-related diseases, but its role in rheumatoid arthritis remains uncertain.
Li Chen, Bangfu Wu, Li Mo, Huimin Chen, Ying Zhao, Tianqi Tan, Liangkai Chen, Yanyan Li, Ping Yao, Yuhan Tang   +9 more
semanticscholar   +1 more source

Artificial intelligence-estimated biological heart age using a 12-lead electrocardiogram predicts mortality and cardiovascular outcomes

Frontiers in Cardiovascular Medicine, 2023
BackgroundThere is a paucity of data on artificial intelligence-estimated biological electrocardiography (ECG) heart age (AI ECG-heart age) for predicting cardiovascular outcomes, distinct from the chronological age (CA).
Yong-Soo Baek, Yong-Soo Baek, Yong-Soo Baek, Dong-Ho Lee, Yoonsu Jo, Sang-Chul Lee, Sang-Chul Lee, Wonik Choi, Wonik Choi, Dae-Hyeok Kim, Dae-Hyeok Kim   +10 more
doaj   +1 more source

Oral health concerns of the 'Sunset Age'

Journal of Medical Evidence, 2023
The steady increase of the greying population globally is causing a demographic transition. Oral health intricately associated with an individual's general health and overall well-being is evolving with ageing.
Pradnya V Kakodkar, Amandeep Kaur, Shivasakthy Manivasakan, Sounyala Rayannavar, Revati Deshmukh, Smita Athavale   +5 more
doaj   +1 more source

The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study

medRxiv, 2023
Objectives: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and
Anna Kankaanpää, A. Tolvanen, L. Joensuu, Katja Waller, A. Heikkinen, J. Kaprio, M. Ollikainen, E. Sillanpää   +7 more
semanticscholar   +1 more source