Results 41 to 50 of about 911,648 (354)

Novel nutraceutical combination restores hepatic deiodinase expression and protein levels under inflammatory conditions: evidence from an in vitro model

Frontiers in Nutrition
Background/objectivesThyroid hormone activation depends on the conversion of T4 to T3 by the selenoenzyme DIO1, whose expression is suppressed by inflammation and oxidative stress.
E. Valeri, F. Loupakis, G. Pasqualetti, E. Paccosi, L. Proietti De Santis, S. Filippi   +5 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Accelerated biological ageing as a complication of cancer therapy

Zaporožskij Medicinskij Žurnal
Aim. The paper aimed to update the study on accelerated biological aging as a complication of cancer therapy with a focus on diagnosing and prognosing the disease course.
O. O. Kovalov, M. Yu. Kolesnyk, O. V. Hancheva, I. F. Bielenichev, K. O. Kovalov   +4 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Biological aging mediates the association between periodontitis and cardiovascular disease: results from a national population study and Mendelian randomization analysis

Clinical Epigenetics
Background The relationship between periodontitis and cardiovascular disease (CVD) has been extensively studied, but the role of biological aging in this relationship remains poorly understood.
Zhaoqi Zhang, Xingru Zhao, Shang Gao, An Li, Ke Deng, Kai Yang, Wei Liu, Mi Du   +7 more
doaj   +1 more source

Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants

Frontiers in Public Health
BackgroundLung function impairment, including preserved ratio impaired spirometry (PRISm) and airflow limitation (AL), is associated with increased risks of mortality and cardiovascular disease; however, the underlying biological mechanisms remain poorly
Jiali Chen, Cheng Wang, Pengyu Duan, Yonghong Bi, Yao Meng, Weiyu Feng, Zhehao Jin, Hangbing Li, Huihui Wang, Xiaoyan Li, Kun Zuo, Xiangcheng Zhao, Longfei Li, Yuling Xing, Lan Luo, Yang Yu, Miao Yu, Muyan Cui, Bing Zhang   +18 more
doaj   +1 more source

Biomarkers of Aging: From Primitive Organisms to Man [PDF]

, 2001
What biological changes take place as we age? Efforts by scientists to uncover the biomarkers of aging, that is, the normal phenomena of growing old, and to separate these inevitable physiologic changes from diseases and other factors.Warns that alleged "
Richard L. Sprott, Robert N. Butler
core  

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Association between blood-derived biological aging and bone mineral density among US adults

BMC Musculoskeletal Disorders
Objective Little is known regarding the association between biological aging and bone mineral density (BMD). This study aimed to assess the effects of biological aging on BMD in US adults.
Longyun Wu, Jing Wang, Xiang Liu, Xueji Wang, Xuefeng Yue   +4 more
doaj   +1 more source

The association between secondhand smoke exposure and accelerated biological aging: A population-based study and Mendelian randomization analysis

Tobacco Induced Diseases
Introduction Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and ...
Yue Zhu⁺, Yufan Gao⁺, Yangguang Lu⁺, Yukai Wang, Ziyu Pan, Huixiang Sheng, Jiajun Li, Yinuo Chen, Jialing Lou, Feng Chen, Fajing Yang   +10 more
doaj   +1 more source