Results 61 to 70 of about 2,895,252 (212)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Other title: Kansas State Advisory Council on Aging report for fiscal years--Other title: Kansas Advisory Council on Aging annual report

open access: yes, 1979
The reports were prepared with the assistance of the Kansas Department on Aging.; Created in 1977 by the Kansas Act on the Aging, the ACA is represents different geographical, social and ethnic groups, with at least half its members being 60 years of age
Kansas Advisory Council on Aging.
core  

Aging and coronary artery calcification: a Mendelian randomization study

open access: yesArchives of Medical Science
Introduction Coronary artery calcification (CAC) is a recognized marker of atherosclerosis and cardiovascular disease (CVD) risk. While CAC is closely linked to aging, its potential as a marker of biological aging remains uncertain. Telomere length (TL),
Mateusz Lejawa   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

[Coalition for Aging LGBT Initial Board Exploratory Meeting Document]

open access: yes, 2015
Initial Board Exploratory Meeting documents from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

Association of pregnancy history and unhealthy lifestyle with biological age acceleration: a large cross-sectional study

open access: yesFrontiers in Public Health
ObjectiveThis study aimed to investigate the association of pregnancy history with biological age (BA) and BA acceleration, and to explore joint effect with lifestyle factors.MethodsThis cross-sectional study used data from the UK Biobank, a population ...
Yuting Yao   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

[Coalition for Aging LGBT Board of Directors Meeting Agenda]

open access: yes, 2015
Board of Directors Meeting agenda document from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

Association between dietary patterns and biological aging among Chinese middle-aged and older adults: evidence from a cross-sectional study

open access: yesFrontiers in Nutrition
BackgroundPrevious studies have shown that dietary patterns are associated with health outcomes in Chinese middle-aged and older adults. However, whether dietary patterns are associated with Klemera-Doubal biological age (KDM-BA) and physiological ...
Xu Zhu   +4 more
doaj   +1 more source

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