Results 81 to 90 of about 911,648 (354)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women

Biology
Telomere length is an index of cellular aging. Healthy lifestyles are associated with reduced oxidative stress and longer telomeres, whereas unhealthy behaviors are related to shorter telomeres and greater biological aging.
Larry A. Tucker, Carson J. Bates
doaj   +1 more source

Premature aging and immune senescence in HIV-infected children [PDF]

, 2016
Objective: Several pieces of evidence indicate that HIV-infected adults undergo premature aging. The effect of HIV and antiretroviral therapy (ART) exposure on the aging process of HIV-infected children may be more deleterious since their immune system ...
Cam\uf3s, Mireia, DE ROSSI, Anita, Del Bianco, Paola, Fortuny, Cl\ue0udia, Freguja, Riccardo, Gianesin, Ketty, Giaquinto, Carlo, Mozzo, Elena, Noguera Julian, Antoni, Petrara, MARIA RAFFAELLA, Rampon, Osvalda, Zanchetta, Marisa   +11 more
core   +1 more source

Time and Biological Age

Arbor: Ciencia, Pensamiento y Cultura, 2013
189
Vargas, Esteban, Espinoza, Ricardo
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Monte Carlo Simulations of Sexual Reproduction

, 1996
Modifying the Redfield model of sexual reproduction and the Penna model of biological aging, we compare reproduction with and without recombination in age-structured populations.
Bernardes, Bernardes, Bernardes, Charlesworth, D. Stauffer, Dasgupta, Kondrashov, Lockshin, Lynch, P.M.C. de Oliveira, Penna, Penna, Penna, R.M.Zorzenon dos Santos, Redfield, Rose, S.Moss de Oliveira, Thoms, Walter   +18 more
core   +1 more source

Effects of aging on identifying emotions conveyed by point-light walkers [PDF]

, 2016
M.G. was supported by EC FP7 HBP (grant 604102), PITN-GA-011-290011 (ABC) FP7-ICT-2013-10/ 611909 (KOROIBOT), and by GI 305/4-1 and KA 1258/15-1, and BMBF, FKZ: 01GQ1002A. K.S.P. was supported by a BBSRC New Investigator Grant. A.B.S. and P.J.B.
Bennett, Patrick J., Giese, Martin A., Pilz, Karin S., Sekuler, Allison B., Spencer, Justine M. Y.   +4 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Translating genetic findings to epigenetics: identifying the mechanisms associated with aging after high-radiation exposure on earth and in space

Frontiers in Public Health
PurposeExposure to radiation is a health concern within and beyond the Earth's atmosphere for aircrew and astronauts in their respective austere environments.
Nathan A. Ruprecht, Sonalika Singhal, Donald Sens, Sandeep K. Singhal, Sandeep K. Singhal   +4 more
doaj   +1 more source