Results 71 to 80 of about 2,895,252 (212)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Aging with developmental disabilities

open access: yes, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Ohio Department of Devvelopmental Disabilities
core  

Other title: [Kansas Department on Aging Overview]

open access: yes, 2009
application/pdf; "March 11, 2009."; Presentation before the Kansas Legislature, Senate Ways and Means Subcommittee on the Kansas Department on Aging, by Secretary Kathy Greenlee, Kansas Department on Aging.Presentation discussing the Governor's budget ...
Greenlee, Kathy.
core   +1 more source

Dietary pattern modifies associations between dietary factors and pace of epigenetic aging

open access: yesFrontiers in Nutrition
IntroductionEpigenetic clocks, DNA methylation-based biomarkers indicating biological aging, are responsive to diet and lifestyle changes, but it remains unclear how specific dietary factors affect these indicators.
Deana M. Ferreri   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity

open access: yesFrontiers in Microbiology
The oral-systemic connection, salivary microbiome, and healthy longevity are increasingly recognized as biologically interconnected. This review summarizes lifespan changes in the salivary microbiome, its links to age-related systemic diseases, and ...
Tongjun Guo   +13 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Be the voice. Take action. Tigether

open access: yes, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Western Reserve Area Agency on Aging   +1 more
core  

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

open access: yesFrontiers in Aging
Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests on an often-unstated assumption: that grip strength serves as a passive readout of systemic ...
Patrick E. Sewell, Christopher Jensen
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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