AutoPlate: Rapid Dose-Response Curve Analysis for Biological Assays [PDF]
Frontiers in Immunology, 2022 The emergence of COVID-19 has emphasised that biological assay data must be analysed quickly to develop safe, effective and timely vaccines/therapeutics.
Phil Palmer +9 more
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Structured data sets of compounds with multi-target and corresponding single-target activity from biological assays [PDF]
Future Science OA, 2021 Aim: Providing compound data sets for promiscuity analysis with single-target (ST) and multi-target (MT) activity, taking confirmed inactivity against targets into account. Methodology: Compounds and target annotations are extracted from screening assays.
Christian Feldmann +2 more
doaj +2 more sources
Copolymer-Coated Gold Nanoparticles: Enhanced Stability and Customizable Functionalization for Biological Assays [PDF]
BiosensorsGold nanoparticles (AuNPs) play a vital role in biotechnology, medicine, and diagnostics due to their unique optical properties. Their conjugation with antibodies, antigens, proteins, or nucleic acids enables precise targeting and enhances biosensing ...
Dario Brambilla +7 more
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Hyperpolarized NMR Probes for Biological Assays [PDF]
Sensors, 2014 During the last decade, the development of nuclear spin polarization enhanced (hyperpolarized) molecular probes has opened up new opportunities for studying the inner workings of living cells in real time.
Sebastian Meier +3 more
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Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays [PDF]
Beilstein Journal of Organic Chemistry, 2017 Three polyaminocyclodextrin materials, obtained by direct reaction between heptakis(6-deoxy-6-iodo)-β-cyclodextrin and the proper linear polyamines, were investigated for their binding properties, in order to assess their potential applications in ...
Marco Russo +5 more
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Frontiers in Medicine, 2022 In 2017, Polish Biobanking Network was established in Poland, within BBMRI.pl project titled “Organization of Polish Biobanking Network within the Biobanking and Biomolecular Resources Research Infrastructure BBMRI-ERIC” as a strategic scientific ...
Agnieszka Matera-Witkiewicz +11 more
doaj +1 more source
The Degradation Product of Ramipril Is Potentially Carcinogenic, Genotoxic and Mutagenic
Applied Sciences, 2023 (1) Background: The aim of this study was to identify the degradation product of ramipril (RAM) formed under dry air and to verify its potential modes of carcinogenicity. We intended to check whether its formation and presence in final dosage forms could
Katarzyna Regulska +3 more
doaj +1 more source
Compound dataset and custom code for deep generative multi-target compound design
Future Science OA, 2021 Aim: Generating a data and software infrastructure for evaluating multi-target compound (MT-CPD) design via deep generative modeling. Methodology: The REINVENT 2.0 approach for generative modeling was extended for MT-CPD design and a large benchmark data
Thomas Blaschke, Jürgen Bajorath
doaj +1 more source
Single nucleus multi-omics regulatory landscape of the murine pituitary
Nature Communications, 2021 The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mouse ...
Frederique Ruf-Zamojski +27 more
doaj +1 more source
Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity
Scientific Reports, 2022 The antimicrobial properties of amylin, a 37-amino acid peptide hormone, co-secreted with insulin from the pancreas, are far less known than its antidiabetic function.
Dorota Dudek +7 more
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