Results 101 to 110 of about 1,041,160 (240)

Machine Learning Strategies When Transitioning between Biological Assays. [PDF]

J Chem Inf Model, 2021
Arvidsson McShane S, Ahlberg E, Noeske T, Spjuth O.   +3 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-Induced Ulcers in Rats

Mediators of Inflammation, 2007
Zullyt B. Zamora Rodríguez, Ricardo González Álvarez, Dailén Guanche, Nelson Merino, Frank Hernández Rosales, Silvia Menéndez Cepero, Yaima Alonso González, Siegfried Schulz   +7 more
doaj   +1 more source

Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Drug Design, Development and Therapy, 2010
Thomas Scior1, José Antonio Guevara-García2, FJ Melendez2, Hassan H Abdallah3, Quoc-Tuan Do4, Philippe Bernard41Facultad de Ciencias Químicas, Universidad Autónoma de Puebla, Pue, Puebla, Mexico; 2Faculty of ...
Thomas Scior, José Antonio Guevara-García, FJ Melendez, et al   +3 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays. [PDF]

RSC Adv, 2023
Abdelshaheed MM, El Subbagh HI, Tantawy MA, Attia RT, Youssef KM, Fawzy IM.   +5 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Corrigendum: Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Drug Design, Development and Therapy, 2010
Error in author listDr Melendez was incorrectly affiliated in "Chimeric design, synthesis, and biological assays of a new nonpeptide insulinmimetic vanadium compound to inhibit protein tyrosine phosphatase 1B", published in Drug Design,
Scior T, Guevara-Garcia JA, Melendez FJ, et al   +3 more
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Spectroscopic, Electrochemical, and Biological Assays of Copper-Binding Molecules for Screening of Different Drugs and Plant Extracts against Neurodegenerative Disorders. [PDF]

ACS Omega, 2022
Brinvillier D, Barrast M, Couderc-Murillo P, Bono-Yagüe J, Rousteau A, Gómez Escribano AP, Palmeira-Mello MV, Doménech-Carbó A, Passe-Coutrin N, Sylvestre M, Vázquez-Manrique RP, Cebrián-Torrejón G.   +11 more
europepmc   +1 more source