Results 121 to 130 of about 9,490,238 (346)
Assay of Thiamine in Biologic Fluids
Abstract A method based on the protozoan Ochromonas malhamensis has been developed for assaying thiamine in biologic fluids. It is sensitive, specific and reproducible. Results by this method agree well with other less convenient methods of thiamine assay.
H, BAKER +5 more
openaire +2 more sources
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1888
Annual report of the Marine Biological Laboratory in Woods Hole. 1888.
Marine Biological Laboratory (Woods Hole MA)
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1892
Annual report of the Marine Biological Laboratory in Woods Hole. 1892.
Marine Biological Laboratory (Woods Hole MA)
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1966
Annual report of the Marine Biological Laboratory in Woods Hole. 1966.
Marine Biological Laboratory (Woods Hole MA)
core
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1895
Annual report of the Marine Biological Laboratory in Woods Hole. 1895.
Marine Biological Laboratory (Woods Hole MA)
core
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source

