Results 141 to 150 of about 6,386,574 (334)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Isolation and In Vitro Activity of Sesquiterpene Lactones from Eremanthus crotonoides as SARS-CoV-2 Protease Inhibitors and Cytotoxic Agents

Molecules
The Jurubatiba Sandbank National Park (PARNA Jurubatiba) is an ecological reserve characterized by harsh environmental conditions, including low rainfall, high sun exposure, and sandy soil.
Patricia Homobono Brito de Moura, Natalie Giovanna da Rocha Ximenes, Beatriz Bastos Santos, Carla Monteiro Leal, Larissa Esteves Carvalho Constant, Stephany da Silva Costa, Shaft Corrêa Pinto, Michelle Frazao Muzitano, Diego Allonso, Ludger A. Wessjohann, Ivana Correa Ramos Leal   +10 more
doaj   +1 more source

Allelopathic Activity of Extracts from Different Brazilian Peanut (Arachis hypogaea L.) Cultivars on Lettuce (Lactuca sativa) and Weed Plants

The Scientific World Journal, 2017
Peanut (Arachis hypogaea L.) is the fourth most consumed oleaginous plant in the world, producing seeds with high contents of lipids, proteins, vitamins, and carbohydrates.
G. S. Casimiro, E. Mansur, G. Pacheco, R. Garcia, I. C. R. Leal, N. K. Simas   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Values of Tm and Ct obtained in pure cultures and experimentally infected biological samples with hDNA for multiplex assays. [PDF]

, 2013
Values of Tm and Ct obtained in pure cultures and experimentally infected biological samples with hDNA for multiplex assays.
Pilar Morata (374445), Rocio Sanjuan-Jimenez (387222), Pilar Bermúdez (5654179), Antonio Alonso (168405), Juan D. Colmenero (374443)   +4 more
core   +1 more source

Caracterización de cepas cubanas de VIH-1 por ensayos biológicos y métodos bioinformáticos Characterization of Cuban strains of HIV-1 by bioassays and bio-information methods

Revista Cubana de Investigaciones Biomédicas, 2010
Mediante ensayos biológicos clásicos se ha podido determinar el uso del correceptor por las cepas de VIH-1, las cuales se han clasificado en R5, X4 o R5/X4, características que guardan relación con el fenotipo NIS o IS y con la evolución clínica.
Leonor Lobaina Barthelemy, Liuber Yans Machado Zaldívar, Enrique Noa Romero, Madeline Blanco de Armas, Leonor Navea Leyva, Marta Dubed Echevarría, Héctor M. Díaz Torres, Felipe Rolo Gómez   +7 more
doaj  

Rapid and inexpensive body fluid identification by RNA profiling-based multiplex High Resolution Melt (HRM) analysis [v2; ref status: indexed, http://f1000r.es/314]

F1000Research, 2014
Positive identification of the nature of biological material present on evidentiary items can be crucial for understanding the circumstances surrounding a crime.
Erin K. Hanson, Jack Ballantyne
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source