Results 161 to 170 of about 3,956,990 (303)

Annual Report - Marine Biological Laboratory, 1986

, 1987
Annual report of the Marine Biological Laboratory in Woods Hole. 1986.
Marine Biological Laboratory (Woods Hole MA)
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Aggregation-Induced Emission-Based Material for Selective and Sensitive Recognition of Cyanide Anions in Solution and Biological Assays. [PDF]

ACS Omega, 2021
Zalmi GA, Nadimetla DN, Kotharkar P, Puyad AL, Kowshik M, Bhosale SV, Bhosale SV.   +6 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1918

, 1919
Annual report of the Marine Biological Laboratory in Woods Hole. 1918.
Marine Biological Laboratory (Woods Hole MA)
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays. [PDF]

Pharmaceuticals (Basel), 2022
Parodi A, Righetti G, Pesce E, Salis A, Tomati V, Pastorino C, Tasso B, Benvenuti M, Damonte G, Pedemonte N, Cichero E, Millo E.   +11 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1924

, 1924
Annual report of the Marine Biological Laboratory in Woods Hole. 1924.
Marine Biological Laboratory (Woods Hole MA)
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Probing pyrazolo-pyrimidines as SIRT2 inhibitors <i>via</i> molecular modelling and biological assays. [PDF]

RSC Med Chem
Musumeci F, Astigiano C, Scarano N, Falesiedi M, Guccione G, Calamano J, Salis A, Miro C, Brullo C, Dentice M, Cichero E, Bruzzone S, Schenone S.   +12 more
europepmc   +1 more source

Static array of droplets and on-demand recovery for biological assays. [PDF]

Biomicrofluidics, 2020
Han SH, Kim J, Lee D.
europepmc   +1 more source