Results 131 to 140 of about 3,956,990 (303)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-Induced Ulcers in Rats

Mediators of Inflammation, 2007
Zullyt B. Zamora Rodríguez, Ricardo González Álvarez, Dailén Guanche, Nelson Merino, Frank Hernández Rosales, Silvia Menéndez Cepero, Yaima Alonso González, Siegfried Schulz   +7 more
doaj   +1 more source

Assay of Properdin in Biological Fluids.

Experimental Biology and Medicine, 1957
Summary1. A sensitive, reproducible assay for properdin is described using spectro-photometric determinations of C'3 content. 2. RP and R3 reagent sera for the properdin assay may be readily prepared from guinea pig serum. 3. RP and R3 from both human and guinea pig sources may be used interchangeably in the reported properdin assay. 4.
openaire   +2 more sources

Annual Report - Marine Biological Laboratory, 1988

, 1989
Annual report of the Marine Biological Laboratory in Woods Hole. 1988.
Marine Biological Laboratory (Woods Hole MA)
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Drug Design, Development and Therapy, 2010
Thomas Scior1, José Antonio Guevara-García2, FJ Melendez2, Hassan H Abdallah3, Quoc-Tuan Do4, Philippe Bernard41Facultad de Ciencias Químicas, Universidad Autónoma de Puebla, Pue, Puebla, Mexico; 2Faculty of ...
Thomas Scior, José Antonio Guevara-García, FJ Melendez, et al   +3 more
doaj  

Annual Report - Marine Biological Laboratory, 1935

, 1936
Annual report of the Marine Biological Laboratory in Woods Hole. 1935.
Marine Biological Laboratory (Woods Hole MA)
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays. [PDF]

J Microbiol Biotechnol, 2022
Liu Y, Ahmed S, Fang Y, Chen M, An J, Yang G, Hou X, Lu J, Ye Q, Zhu R, Liu Q, Liu S.   +11 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1943

, 1944
Annual report of the Marine Biological Laboratory in Woods Hole. 1943.
Marine Biological Laboratory (Woods Hole MA)
core