Results 191 to 200 of about 3,956,990 (303)

E-GuARD: expert-guided augmentation for the robust detection of compounds interfering with biological assays. [PDF]

J Cheminform
Palmacci V, Nahal Y, Welsch M, Engkvist O, Kaski S, Kirchmair J.   +5 more
europepmc   +1 more source

Dimensional distribution control of elongate mineral particles for their use in biological assays. [PDF]

MethodsX, 2020
Vigliaturo R, Choi JK, Pérez-Rodríguez I, Gieré R.   +3 more
europepmc   +1 more source

Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand. [PDF]

RSC Adv, 2022
Höing A, Struth R, Beuck C, Rafieiolhosseini N, Hoffmann D, Stauber RH, Bayer P, Niemeyer J, Knauer SK.   +8 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1952

, 1952
Annual report of the Marine Biological Laboratory in Woods Hole. 1952.
Marine Biological Laboratory (Woods Hole MA)
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exploring Schiff base bromhexine derivatives: study on synthesis, characterization, biological assays, molecular docking. [PDF]

Future Med Chem
Yasmeen Z, Khan MA, Masood A, Akram T, Breena, Bhat MA, Raza A, Ahmed J, Khaliq S, Al-Omar MA, Ullah F.   +10 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Molecular docking, derivatization, characterization and biological assays of amantadine. [PDF]

Future Med Chem
Yasmeen Z, Khan MA, Ahmad I, Ullah F, Awan B, Akram MT, Khan MR.   +6 more
europepmc   +1 more source

Tetrazole and acylsulfonamide bioisosteric replacements of the carboxylic acid in a dual MCL-1/BCL-x_L inhibitor are tolerated. [PDF]

RSC Adv, 2023
Chen L, Lowe B, Fletcher S.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source