Results 211 to 220 of about 9,490,238 (346)

Microfluidic Systems with Embedded Cell Culture Chambers for High-Throughput Biological Assays. [PDF]

ACS Appl Bio Mater, 2020
Jaberi A, Monemian Esfahani A, Aghabaglou F, Park JS, Ndao S, Tamayol A, Yang R.   +6 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1918

, 1919
Annual report of the Marine Biological Laboratory in Woods Hole. 1918.
Marine Biological Laboratory (Woods Hole MA)
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

PEGASUS: Unlocking Polarity in Cell-Permeable Cyclic Peptides Using AI Models Built on Massively Parallel Biological Assays. [PDF]

J Med Chem
Baker C, Acquah FA, Chivukula LG, Wu L, Philippe-Venec L, Abedi M, Tao Y, Ramírez D, McCoy MD, Moore B, Asher JO.   +10 more
europepmc   +1 more source

Small molecular adjuvants repurpose antibiotics towards Gram-negative bacterial infections and multispecies bacterial biofilms. [PDF]

Chem Sci, 2023
Dey R, Mukherjee S, Mukherjee R, Haldar J.   +3 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1936

, 1937
Annual report of the Marine Biological Laboratory in Woods Hole. 1936.
Marine Biological Laboratory (Woods Hole MA)
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

E-GuARD: expert-guided augmentation for the robust detection of compounds interfering with biological assays. [PDF]

J Cheminform
Palmacci V, Nahal Y, Welsch M, Engkvist O, Kaski S, Kirchmair J.   +5 more
europepmc   +1 more source

Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligand. [PDF]

RSC Adv, 2022
Höing A, Struth R, Beuck C, Rafieiolhosseini N, Hoffmann D, Stauber RH, Bayer P, Niemeyer J, Knauer SK.   +8 more
europepmc   +1 more source

Annual Report - Marine Biological Laboratory, 1952

, 1952
Annual report of the Marine Biological Laboratory in Woods Hole. 1952.
Marine Biological Laboratory (Woods Hole MA)
core