Results 231 to 240 of about 9,490,238 (346)

Tetrazole and acylsulfonamide bioisosteric replacements of the carboxylic acid in a dual MCL-1/BCL-x_L inhibitor are tolerated. [PDF]

RSC Adv, 2023
Chen L, Lowe B, Fletcher S.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chitosan-Stabilized Silver–Nimesulide Coordination Complex with Enhanced Anti-Inflammatory and Redox-Modulating Activity

ACS Omega
Luis Eduardo M Narvaez, Kely C. N. Lima, Roseane G. Ferreira, Silvia Letícia de F. Gaspar, Victor Ricardo C. Sousa, Rayane Caroline dos S Pereira, Jaqueline D. N. Martins, Lucas da S. Gato, Sávio M. dos Santos, Lisa Maria M. de A. Souza, Carla Carolina F. Meneses, Paulo Robson M. de Sousa, Cláudio N. Alves, Marta C. Monteiro   +13 more
doaj   +1 more source

Discovery of Novel Thiazole-Based SIRT2 Inhibitors as Anticancer Agents: Molecular Modeling, Chemical Synthesis and Biological Assays. [PDF]

Int J Mol Sci
Piacente F, Guccione G, Scarano N, Lunaccio D, Miro C, Abbotto E, Salis A, Tasso B, Dentice M, Bruzzone S, Cichero E, Millo E.   +11 more
europepmc   +1 more source

Isoamphipathic antibacterial molecules regulating activity and toxicity through positional isomerism. [PDF]

Chem Sci, 2023
Barman S, Mukherjee S, Jolly L, Troiano C, Grottesi A, Basak D, Calligari P, Bhattacharjee B, Bocchinfuso G, Stella L, Haldar J.   +10 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Integration of In Vitro and In Silico Results From Chemical and Biological Assays of <i>Rheum turkestanicum</i> and <i>Calendula officinalis</i> Flower Extracts. [PDF]

Food Sci Nutr
Korpayev S, Zengin G, Ak G, Glamočlija J, Soković M, Aničić N, Gašić U, Stojković D, Agamyradov M, Cetiz MV, Agamyradova G.   +10 more
europepmc   +1 more source

Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays. [PDF]

Sci Rep, 2020
Pinto IC, Seibert JB, Pinto LS, Santos VR, de Sousa RF, Sousa LRD, Amparo TR, Dos Santos VMR, do Nascimento AM, de Souza GHB, Vasconcellos WA, Vieira PMA, Andrade ÂL.   +12 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit Validation by Biological Assays. [PDF]

J Chem Inf Model
Pakamwong B, Thongdee P, Kamsri B, Phusi N, Taveepanich S, Chayajarus K, Kamsri P, Punkvang A, Hannongbua S, Sangswan J, Suttisintong K, Sureram S, Kittakoop P, Hongmanee P, Santanirand P, Leanpolchareanchai J, Spencer J, Mulholland AJ, Pungpo P.   +18 more
europepmc   +1 more source