Results 151 to 160 of about 9,777,305 (324)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Body sizes of species determining the success of biological control in a three-level food chain. [PDF]

Sci Rep
Campillay-Llanos W, Ortega-Farías S, Díaz GA, López-Flores MM.   +3 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Evaluation of the direct cost of chronic viral hepatitis B in patients monitored at the hepato-gastroenterology department of the Yalgado OUEDRAOGO University Hospital. [PDF]

BMC Gastroenterol
Ouedraogo K, Toure AO, Bocoum FY, Diallo D, Delamou A, Kouanda S.   +5 more
europepmc   +1 more source

Biological availability of minerals and trace elements: a nutritional overview

, 1982
Irwin H. Rosenberg, Noel W. Solomons
openalex   +1 more source

THE NATURE AND BIOLOGICAL AVAILABILITY OF ALMOND CARBOHYDRATES [PDF]

Journal of Biological Chemistry, 1930
Agnes Fay Morgan, Florence Blume, Clara M. Strauch   +2 more
openaire   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus data repository. [PDF]

Genome Biol
Huang YN, Jaiswal PV, Rajes A, Yadav A, Yu D, Liu F, Scheg G, Shih E, Boldirev G, Nakashidze I, Sarkar A, Mehta JH, Wang K, Patel KK, Mirza MAB, Hapani KC, Peng Q, Ayyala R, Guo R, Kapur S, Ramesh T, Ciorbă D, Munteanu V, Bostan V, Dimian M, Abedalthagafi MS, Mangul S.   +26 more
europepmc   +1 more source

Selenium Content of Feedstuffs and Biological Availability of Selenium in Chicks

, 1981
Haruhisa IKUMO, Minoru Yoshida
openalex   +2 more sources

Availability, Health-Care Costs, and Utilization Patterns of Biologics in Taiwan [PDF]

, 2012
Chee-Ruey Hsieh, Ya‐Ming Liu
openalex   +1 more source