Results 221 to 230 of about 2,706,945 (355)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

LinAge2: providing actionable insights and benchmarking with epigenetic clocks. [PDF]

NPJ Aging
Fong S, Denisov KA, Nefedova AA, Kennedy BK, Gruber J.   +4 more
europepmc   +1 more source

Biological evaluations of commercial dicalcium phosphates as sources of available phosphorus for broiler chicks

, 1997
FR Lima, CX Mendonca, J C Alvarez, J M F Garzillo, Esleibe Ghion, PM Leal   +5 more
openalex   +1 more source

Biochar application rate affects biological nitrogen fixation in red clover conditional on potassium availability [PDF]

, 2014
Shamim Mia, Jan Willem van Groenigen, Tess F. J. van de Voorde, Natalie J. Oram, Т. Martijn Bezemer, Liesje Mommer, Simon Jeffery   +6 more
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

MetAssimulo 2.0: a web app for simulating realistic 1D and 2D metabolomic 1H NMR spectra. [PDF]

Bioinformatics
Yan Y, Jiménez B, Judge MT, Athersuch T, De Iorio M, Ebbels TMD.   +5 more
europepmc   +1 more source

Availability and restrictions in the use of biologic therapy in Poland [PDF]

, 2015
Oliwia Bachanek, Jakub Mitura, Jakub Pawlikowski   +2 more
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

UnifiedGreatMod: a new holistic modelling paradigm for studying biological systems on a complete and harmonious scale. [PDF]

Bioinformatics
Aucello R, Pernice S, Tortarolo D, Calogero RA, Herrera-Rincon C, Ronchi G, Geuna S, Cordero F, Lió P, Beccuti M.   +9 more
europepmc   +1 more source

Biological Sensor for Sucrose Availability: Relative Sensitivities of Various Reporter Genes

, 2001
William G. Miller, Maria T. Brandl, Beatriz Quiñones, Steven E. Lindow   +3 more
openalex   +1 more source