Results 81 to 90 of about 2,706,945 (355)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
, 2020 The widespread availability of high-dimensional biological data has made the simultaneous screening of numerous biological characteristics a central statistical problem in computational biology.
Boileau, Philippe +3 more
core +1 more source
Seasonal development of iron limitation in the sub-Antarctic zone [PDF]
Biogeosciences, 2018 The seasonal and sub-seasonal dynamics of iron availability within the sub-Antarctic zone (SAZ; ∼ 40–45° S) play an important role in the distribution, biomass and productivity of the phytoplankton community.
T. J. Ryan-Keogh +7 more
doaj +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
An Evaluation of the Biological Availability of Chloramphenicol [PDF]
, 2017 The biological availability of chloramphenicol from different commercial preparations was investigated. Methods used to evaluate the in vitro release were disintegration, de-aggregation and dissolution tests and particle size measurement.
Koeleman, HA, van Oudtshoorn, MCB
core +1 more source
Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs [PDF]
arXiv, 2011 Detailed and systematic understanding of the biological effects of millions of available compounds on living cells is a significant challenge. As most compounds impact multiple targets and pathways, traditional methods for analyzing structure-function relationships are not comprehensive enough.
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Green manure crops for low fertility soils [PDF]
, 2019 Organic crop production is growing, but crop yields are still below potential. The purpose of our project “Nutrients for higher organic yields (NutHY)” is to increase yields and resource efficiency in organic crop production by optimizing nutrient supply.
Hansen, Veronika +2 more
core
Listen to genes : dealing with microarray data in the frequency domain [PDF]
, 2009 Background: We present a novel and systematic approach to analyze temporal microarray data. The approach includes normalization, clustering and network analysis of genes.
A Claridge-Chang +32 more
core +3 more sources
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source