Results 251 to 260 of about 67,445 (310)

Resetting the “biological clock”

The Onco Fertility Journal, 2019
openaire   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Correlation of Biological Clock with General and Dental Health

, 2019
Rishabh Bhanot, Dr. Sheikh Javeed Ahmad, Makrand Sapat, N. Vinaya, Syeda Ayesha, Deepesh Mathur, Rahul Tiwari   +6 more
openalex   +1 more source

A Novel Framework for the Design of Minimized Epigenetic Clocks Using the Analysis of DNA Methylation Heterogeneity. [PDF]

Int J Mol Sci
Romanov SE, Karetnikov DI, Kalashnikova DA, Polivcev DE, Osipov YA, Maksimov DA, Antoshina PA, Shloma VV, Samoilova EM, Ivanova AA, Karimov RF, Tkalin AN, Shevchenko AA, Kalsin VA, Baklaushev VP, Laktionov PP.   +15 more
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Evolutionary mechanisms of circadian clocks

Open Life Sciences, 2007
Rodrigo Guillermo, Carrera Javier, Jaramillo Alfonso   +2 more
doaj   +1 more source

Causal impact of genetically-determined fish and fish oil intake on epigenetic age acceleration and related serum markers. [PDF]

Hum Genomics
Fabian P, Blander G, Deehan R, Torkamani A, Nogal B.   +4 more
europepmc   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Methylation-based biological age and cardiotoxicity risk in breast cancer patients treated with trastuzumab. [PDF]

Cardiooncology
Mammadova J, Richards A, Gonzalez-Torriente A, Adler ER, Cruz RJ, Palfi S, Lee DH, Sam C, Al-Jumayli M, Berglund A, Park JY, Alomar M, Kresovich JK.   +12 more
europepmc   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source