Results 261 to 270 of about 72,901 (315)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Biological clocks

, 1970
openaire   +1 more source

Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players. [PDF]

Sci Rep
Pérez RF, Lecumberri-Arteta J, Kulis M, Botta-Orfila T, Rodríguez-Vilarrupla A, Yanguas X, Ferrer E, Rodas G, Martin-Subero JI.   +8 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis. [PDF]

Aging Cell
Diniz BS, Zhao S, Drouard G, Vuoksimaa E, Ollikainen M, Lenze EJ, Xu M, Fortinsky RH, Kuchel GA, Kaprio J, Kuo CL.   +10 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Regulation of Metabolic Rhythms by Glial Clocks. [PDF]

J Biol Rhythms
Carvalhas-Almeida C, Noya SB, Wu T, Rita Álvaro A, Cavadas C, Williams JA, Sehgal A.   +6 more
europepmc   +1 more source

Speeding Up Time: New Urinary Peptide Clock Associates Greater Air Pollution Exposures with Faster Biological Aging

Silke Schmidt
openalex   +1 more source

An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes. [PDF]

Nat Commun
Mavrommatis C, Belsky DW, Ying K, Moqri M, Campbell A, Richmond A, Gladyshev VN, Chandra T, McCartney DL, Marioni RE.   +9 more
europepmc   +1 more source

Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis. [PDF]

Mult Scler
Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS.   +27 more
europepmc   +1 more source