Results 101 to 110 of about 1,829,061 (296)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan

Journal of Ethnobiology and Ethnomedicine, 2019
Background The ethnic groups in Gilgit-Baltistan have been utilizing local resources in their centuries-old traditional healing system. Most tribes within these ethnic groups still rely on traditional healing systems.
Muhammad Asad Salim, Sailesh Ranjitkar, Robbie Hart, Tika Khan, Sajid Ali, Chandni Kiran, Asma Parveen, Zahra Batool, Shanila Bano, Jianchu Xu   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Economic evaluation of biological invasions: A survey [PDF]

Invasive species are one of the main reasons for the loss of biodiversity. Therefore, national strategies are developed to deal with biological invasions.
Born, Wanda, Bräuer, Ingo, Rauschmayer, Felix   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Enhancing chemical and biological diversity by co-cultivation. [PDF]

Front Microbiol, 2023
Selegato DM, Castro-Gamboa I.
europepmc   +1 more source

Combining biological approaches to highlight the evolution of Musa complex [PDF]

, 2008
The diversity of the banana complex can be deciphered only by jointly characterizing the original wild species and their relatives, the primitive diploid forms and the triploid varieties.
Bakry, Frédéric, Carreel, Françoise, Hippolyte, Isabelle, Horry, Jean-Pierre, Jenny, Christophe, Lebot, Vincent, Perrier, Xavier   +6 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution

Nature Communications
Theory predicts that compensatory genetic changes reduce negative indirect effects of selected variants during adaptive evolution, but evidence is scarce.
Xiao Zhang, Mark Blaxter, Jonathan M. D. Wood, Alan Tracey, Shane McCarthy, Peter Thorpe, Jack G. Rayner, Shangzhe Zhang, Kirstin L. Sikkink, Susan L. Balenger, Nathan W. Bailey   +10 more
doaj   +1 more source

Taxonomic Report on Pichia acetica sp. nov., a Novel Acetic Acid-Utilizing Yeast Species, and Three Unrecorded Pichia Species in Korea

Mycobiology
Pichia species are widely distributed across various ecosystems and have industrial significance, particularly in wine fermentation and bioproduct synthesis.
Chorong Ahn, Mi Jin Jeon, Soonok Kim, Changmu Kim   +3 more
doaj   +1 more source