Results 81 to 90 of about 1,829,061 (296)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Presence of a loner strain maintains cooperation and diversity in well-mixed bacterial communities [PDF]

, 2016
Cooperation and diversity abound in nature despite cooperators risking exploitation from defectors and superior competitors displacing weaker ones. Understanding the persistence of cooperation and diversity is therefore a major problem for evolutionary ...
Biernaskie, Jay, Gardner, Andy, Inglis, Robert, Kümmerli, Rolf   +3 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Complex dynamics in coevolution models with ratio-dependent functional response

, 2009
We explore the complex dynamical behavior of two simple predator-prey models of biological coevolution that on the ecological level account for interspecific and intraspecific competition, as well as adaptive foraging behavior.
Bascompte, Caldarelli, Chowdhury, Chowdhury, Christensen, Crosby, di Collobiano, Drossel, Drossel, Eigen, Eigen, Filotas, Gavrilets, Gavrilets, Gavrilets, Getz, Hall, Kauffman, Kauffman, Krebs, Krebs, Kuang, Martinez, Murray, Namba, Newman, Newman, Nunes Amaral, Per Arne Rikvold, Procaccia, Qin, Quince, Quince, Resit, Rikvold, Rikvold, Rikvold, Rikvold, Rossberg, Rossberg, Sevim, Skalski, Solé, Thompson, Thompson, Verhulst, Yoshida, Yoshida, Zia   +48 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Fluctuations in models of biological macroevolution

, 2005
Fluctuations in diversity and extinction sizes are discussed and compared for two different, individual-based models of biological coevolution. Both models display power-law distributions for various quantities of evolutionary interest, such as the ...
Rikvold, Per Arne
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Protection of biological diversity [PDF]

, 2012
Life comes in an almost unending variety of shapes and sizes, and we all depend on this biodiversity for our food, health and security. This incredible natural wealth is a priceless resource.
Miroshnichenko, Y.V.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ancistrohaptor forficata sp. n. (Monopisthocotyla, Dactylogyridae): A New Parasite of Triportheus signatus (Characiformes, Triportheidae) from the Salgado River, Brazil

Parasitologia
The genus Ancistrohaptor was proposed to accommodate monopisthocotylans flatworms parasitic on the gills of species of the genus Triportheus in Manaus, Amazonas state, Brazil.
Maria Fernanda Barros Gouveia Diniz, Wallas Benevides Barbosa de Sousa, Priscilla de Oliveira Fadel Yamada, Fábio Hideki Yamada   +3 more
doaj   +1 more source