Results 41 to 50 of about 83,265 (261)

Haplodiploidy and the evolution of eusociality : split sex ratios

, 2014
The authors acknowledge Balliol College, the European Research Council, the Leverhulme Trust, the Royal Society, and the Programa Doutoral em Biologia Computacional–Instituto Gulbenkian de Ciencia/Fundacao para a Ciencia e Tecnologia (SFRH/BD/33206/2007)
West, Stuart A., Alpedrinha, Joao, Gardner, Andy   +2 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Satellite‐Derived NDVI Predicts Forage Availability in a Wild Ungulate System: Ground‐Truthing Using Field‐Collected Vegetation Biomass

Ecology and Evolution
Satellite‐derived vegetation indices provide a powerful means to quantify habitat variation in long‐term ecological studies, but their reliability as proxies for forage availability in wild herbivore populations remains underexplored.
Shane Butt, Kirsty Macphie, Richard S. Turner, Sean J. Morris, Alison Morris, Robin Pakeman, Loeske E. B. Kruuk, J. M. Pemberton, H. Froy   +8 more
doaj   +1 more source

Origin of Life: The Point of No Return

Life, 2020
Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important ...
Dimiter Kunnev
doaj   +1 more source

Seasonal variation in defense behavior in European and scutellata-hybrid honey bees (Apis mellifera) in Southern California

Scientific Reports, 2023
Nest defense in the honey bee (Apis mellifera) is a complex collective behavior modulated by various interacting social, environmental, and genetic factors. Scutellata-hybrid (“Africanized”) honey bees are usually considered to be far more defensive than
Daniela Zarate, Brandon Mukogawa, Joshua Kohn, James C. Nieh   +3 more
doaj   +1 more source

Biological constraints as norms in evolution [PDF]

History and Philosophy of the Life Sciences, 2022
AbstractBiology seems to present local and transitory regularities rather than immutable laws. To account for these historically constituted regularities and to distinguish them from mathematical invariants, Montévil and Mossio (Journal of Theoretical Biology 372:179–191, 2015) have proposed to speak of constraints.
openaire   +2 more sources

Dynamics of sex ratio and female unmatedness under haplodiploidy

, 2014
Haplodiploid sex determination allows unmated females to produce sons. Consequently, a scarcity of males may lead to a significant proportion of females remaining unmated, which may in turn give rise to a surfeit of males in the following generation ...
Andy Gardner, Gardner, Andy
core   +1 more source