Results 61 to 70 of about 1,894,620 (286)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Exploratory Temporal and Evolutionary Insights into the Filoviridae Family Through Multiprotein Phylogeny

Microorganisms
Filoviruses are among the most lethal viral human pathogens known, with significant relevance to public health, yet their evolutionary history remains poorly resolved.
Thiago S. Messias, Kaique C. P. Silva, Narciso A. Vieira, Gislaine A. Querino, Elaine C. Marcos, Mateus J. de C. Stefani, Ana P. R. Battochio, Thaís M. Oliveira, Ivan S. Vieira, Aline S. Ibanes, Taylor E. T. Olivo, Edson C. de Melo, Silvia C. Arantes, Pedro C. R. da Luz, Maria G. R. Mengoa, Simone Soares   +15 more
doaj   +1 more source

Entropy and Entropy Production: Old Misconceptions and New Breakthroughs

Entropy, 2013
Persistent misconceptions existing for dozens of years and influencing progress in various fields of science are sometimes encountered in the scientific and especially, the popular-science literature.
Leonid M. Martyushev
doaj   +1 more source

Migration dynamics of an important rice pest: The brown planthopper (Nilaparvata lugens) across Asia—Insights from population genomics

Evolutionary Applications, 2020
Introduction Brown planthoppers (Nilaparvata lugens) are the most serious insect pests of rice, one of the world's most important staple crops. They reproduce year‐round in the tropical parts of their distribution, but cannot overwinter in the temperate ...
James P. Hereward, Xuhong Cai, Ambrocio Melvin A. Matias, Gimme H. Walter, Chenxi Xu, Yongmo Wang   +5 more
doaj   +1 more source

Biological Individuals [PDF]

, 2019
The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual?
Barker, Matthew J., Wilson, Robert A.
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Exploring Comparative Physiology and Evolution: Understanding Homologous Structures with Students

Current: The Journal of Marine Education
A summer course designed for high school students compared different morphological features that evolved in response to locomotion. This course, as part of the USC Leslie and Bill McMorrow Neighborhood Academic Initiative (USC NAI), provided 20 students ...
Dieuwertje J. Kast, Cecily Pulver, Jim Dines, Matt Dean   +3 more
doaj   +1 more source

Machine learning-guided directed evolution for protein engineering [PDF]

, 2019
Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H., Wu, Zachary, Yang, Kevin K.   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source