Results 111 to 120 of about 1,821,786 (305)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Integrated ecological modelling for decision support in river management: a lowland river case study (Cauca river in Colombia) [PDF]

, 2010
Several practical concepts and software systems have been recently developed in the issue of environmental decision support. However, the application of ecological modelling approaches that integrate hydrodynamic, physical-chemical, and biological ...
Galvis, Alberto, Goethals, Peter, Holguin Gonzalez, Javier   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Caracterização das condições ambientais de um rio neotropical a partir da densidade, composição e riqueza de taxa de invertebrados bênticos = Environmental conditions of a neo-tropical river featuring density, composition and taxa richness of bentic invertebrates

Acta Scientiarum: Biological Sciences, 2009
As atividades antrópicas podem causar profundas alterações nas características físicas e químicas dos ambientes aquáticos, assim como na biota. Muitas espécies de invertebrados bentônicos podem auxiliar a indicação dessas alterações.
Roger Paulo Mormul, Sidnei Pressinatte Junior, Luiz Alberto Vieira, Alexandre Monkolski, Edinéia Barbosa Povh   +4 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients. [PDF]

Int J Mol Sci, 2023
Vialaret J, Vignon M, Badiou S, Baptista G, Fichter L, Dupuy AM, Maceski AM, Fayolle M, Brousse M, Cristol JP, Jeandel C, Hirtz C, Lehmann S.   +12 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Environmental and biological monitoring of exposure to mercury and assessment of its effects on neurobehavioral disorders; A case-control study among workers in a unit of petroleum industry

بهداشت و ایمنی کار, 2018
Introduction: Mercury, in different form can induce adverse effects on various organs especially central nervous system. The aim of this study was to determine concentration of mercury in inhalation and urine of the exposed worker and to investigate the ...
Mohammad Hamid Ijazi, Sara Salarian, Majid Bagheri Hosseinabadi   +2 more
doaj  

Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination. [PDF]

Int J Environ Res Public Health, 2023
Ndaw S, Remy A.
europepmc   +1 more source

Science-based restoration monitoring of coastal habitats, Volume One: A framework for monitoring plans under the Estuaries and Clean Waters Act of 2000 (Public Law 160-457) [PDF]

, 2003
Executive Summary: The Estuary Restoration Act of 2000 (ERA), Title I of the Estuaries and Clean Waters Act of 2000, was created to promote the restoration of habitats along the coast of the United States (including the US protectorates and the Great ...
Bellmer, Russell J., Burrows, Felicity M., Gayaldo, Perry F., Lozano, Stephen J., McTigue, Teresa A., Merkey, David H., Nickens, Amy D., Pinit, P. Thomas, Polmateer, Pamela J., Thayer, Gordon W.   +9 more
core