Results 121 to 130 of about 1,821,786 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Development of a specific electrochemical sensor for occupational and environmental monitoring of diazinon

بهداشت و ایمنی کار, 2017
Diazinon is commonly used for pest control in the agricultural fields because of its relatively low cost and high efficiency. Due to the increasing application of pesticides, reliable and accurate analytical methods are necessary for their monitoring ...
Monireh Khadem, Farnoush Faridbod, Parviz Norouzi, Abbas Foroushani Rahimi Foroushani, Mohammad Reza Ganjali, Seyed Jamaleddin Shahtaheri, Rasoul Yarahmadi   +6 more
doaj  

HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure. [PDF]

Int J Environ Res Public Health, 2022
Jones K, Galea KS, Scholten B, Loikala M, Porras SP, Bousoumah R, Ndaw S, Leese E, Louro H, Silva MJ, Viegas S, Godderis L, Verdonck J, Poels K, Gӧen T, Duca RC, Santonen T, Hbm Eu Diisocyanates Study Team.   +17 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reservoir Operational Strategies for Sustainable Sand Management in the Colorado River

Water Resources Research
Climate change and increasing societal demands for water pose challenges for the management of dam‐regulated rivers. Management decisions impact the environment of these rivers, creating the need to balance societal needs with environmental conservation.
Gerard Salter, David J. Topping, Jian Wang, John C. Schmidt, Charles B. Yackulic, Lucas S. Bair, Erich R. Mueller, Paul E. Grams   +7 more
doaj   +1 more source

Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data. [PDF]

Int J Environ Res Public Health, 2022
Leso V, Sottani C, Santocono C, Russo F, Grignani E, Iavicoli I.   +5 more
europepmc   +1 more source

Aura Ozone Monitoring Garden Lithograph [PDF]

, 2006
This lithograph describes where ozone is found, how it is formed, and the effects of ozone on biological processes. How and why NASA studies ozone is covered along with how individuals can monitor ground level (tropospheric) ozone by starting their own ...

core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

An Investigation of the Potential of Vibrio fischeri Bacterium for Monitoring of Oil Pollution in Aqueous Media

علوم آب و خاک, 2020
Growing concerns about water pollution and its potentially harmful effects on human being have stimulated serious efforts to develop reliable biological monitoring techniques.
M. Mirjani, M. Soleimani, V. Salari
doaj