Results 61 to 70 of about 330,773 (377)

Modeling pN2 through Geological Time: Implications for Planetary Climates and Atmospheric Biosignatures [PDF]

, 2016
Nitrogen is a major nutrient for all life on Earth and could plausibly play a similar role in extraterrestrial biospheres. The major reservoir of nitrogen at Earth's surface is atmospheric N2, but recent studies have proposed that the size of this ...
Buick, R., Johnson, B., Kipp, M. A., Koehler, M. C., Schwieterman, E. W., Stüeken, E. E.   +5 more
core   +2 more sources

Bedrock Nitrogen Weathering Stimulates Biological Nitrogen Fixation [PDF]

The Bulletin of the Ecological Society of America, 2019
AbstractGlobal ecosystem models suggest that bedrock nitrogen (N) weathering contributes 10–20% of total N inputs to the natural terrestrial biosphere and >38% of ecosystem N supplies in temperate forests specifically. Yet, the role of rock N weathering in shaping ecological processes and biogeochemical fluxes is largely unknown.
Katherine A. Dynarski, Scott L. Morford, Scott A. Mitchell, Benjamin Z. Houlton   +3 more
openaire   +2 more sources

Extracellular electron transfer drives ATP synthesis for nitrogen fixation by Pseudomonas stutzeri

Electrochemistry Communications, 2023
Biological nitrogen fixation is a key step in the reduction of N2 to available nitrogen in the global nitrogen cycle. Pseudomonas stutzeri A1501 is an electroactive diazotroph and previous studies have shown that its nitrogen fixation performance is ...
Shanshan Chen, Xintong Han, Shuyi Xie, Yuting Yang, Xianyue Jing, Tiangang Luan   +5 more
doaj   +1 more source

Human alteration of the global nitrogen and phosphorus soil balances for the period 1970-2050 [PDF]

, 2009
The Millennium Ecosystem Assessment scenarios for 2000 to 2050 describe contrasting future developments in agricultural land use under changing climate. Differences are related to the total crop and livestock production and the efficiency of nutrient use
Beusen, A.H.W., Billen, G., Bouwman, A.F.   +2 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Regulation of Biological Nitrogen Fixation [PDF]

The Journal of Nutrition, 2000
Biological nitrogen fixation, a process found only in some prokaryotes, is catalyzed by the nitrogenase enzyme complex. Bacteria containing nitrogenase occupy an indispensable ecological niche, supplying fixed nitrogen to the global nitrogen cycle. Due to this inceptive role in the nitrogen cycle, diazotrophs are present in virtually all ecosystems ...
C M, Halbleib, P W, Ludden
openaire   +2 more sources

Soil P Status and Nitrogen Fixation on Organic Dairy Farms in Ontario and Nova Scotia [PDF]

, 2010
Legumes are a key source of nitrogen (N) in organic production systems. However, there is evidence that reduced inputs may be leading to deficient soil phosphorus (P) on some organic dairy farms (Roberts et. al. 2008).
Juurlink, Shelly, Lynch, Derek, Main, Michael, Schneider, Kim, Voroney, Paul, Ward, Amanda   +5 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Century of Synthetic Fertilizer: 1909-2009 [PDF]

, 2009
This year marks a centenary of the synthetic fertilizer industry. German chemists, Fritz Haber and Carl Bosch, in 1909 demonstrated their industrial process for the manufacture of ammonia. The achievement won them accolades including Nobel Prizes.
Paull, John
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source