Results 91 to 100 of about 70,807 (316)

Ontological theory for ontological engineering: Biomedical systems information integration [PDF]

, 2004
Software application ontologies have the potential to become the keystone in state-of-the-art information management techniques. It is expected that these ontologies will support the sort of reasoning power required to navigate large and complex ...
Ceusters, Werner, Fielding, James M., Simon, Jonathan, Smith, Barry   +3 more
core   +1 more source

Anatomical information science [PDF]

, 2005
The Foundational Model of Anatomy (FMA) is a map of the human body. Like maps of other sorts – including the map-like representations we find in familiar anatomical atlases – it is a representation of a certain portion of spatial reality as it exists at ...
Kumar, Anand, Mejino, Jose L V, Rosse, Cornelius, Schultz, Stefan, Smith, Barry   +4 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Constructing a lattice of Infectious Disease Ontologies from a Staphylococcus aureus isolate repository [PDF]

, 2012
A repository of clinically associated Staphylococcus aureus (Sa) isolates is used to semi‐automatically generate a set of application ontologies for specific subfamilies of Sa‐related disease.
Cowell, Lindsay G., Goldfain, Albert, Smith, Barry   +2 more
core   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Spatial location and its relevance for terminological inferences in bio-ontologies

BMC Bioinformatics, 2007
Background An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggregation and containment.
Markó Kornél, Schulz Stefan, Hahn Udo
doaj   +1 more source

An automated identification and analysis of ontological terms in gastrointestinal diseases and nutrition-related literature provides useful insights [PDF]

, 2018
With an unprecedented growth in the biomedical literature, keeping up to date with the new developments presents an immense challenge. Publications are often studied in isolation of the established literature, with interpretation being subjective and ...
Gerasimidis, Konstantinos, Ijaz, Umer Zeeshan, Koci, Orges, Logan, Michael, Russell, Richard K., Svolos, Vaios   +5 more
core   +2 more sources

Ontology Engineering Techniques for Biological Data

Journal of Computers, 2014
Now-a-days the challenge that is increasingly being faced in different domains is how to integrate a large amount of available data and information for a particular domain. The purpose of this integration of data is to get an easy understanding of that particular domain.
Asma Fardoos, Jamshaid Iqbal Janjua, Amjad Farooq   +2 more
openaire   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source