Results 71 to 80 of about 70,807 (316)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Ontology (Science) [PDF]

, 2008
Increasingly, in data-intensive areas of the life sciences, experimental results are being described in algorithmically useful ways with the help of ontologies.
Barry Smith
core   +2 more sources

ontoFAST: Interactive Annotation of Characters with Biological Ontologies [PDF]

, 2021
Sergei Tarasov
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

MetNetGE: interactive views of biological networks and ontologies

BMC Bioinformatics, 2010
Background Linking high-throughput experimental data with biological networks is a key step for understanding complex biological systems. Currently, visualization tools for large metabolic networks often result in a dense web of connections that is ...
Jia Ming, Choi Suh-Yeon, Reiners Dirk, Wurtele Eve S, Dickerson Julie A   +4 more
doaj   +1 more source

Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD. [PDF]

PLoS ONE, 2011
Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence worldwide. The primary aim of this study was to identify genes and gene ontologies associated with COPD severity.
Santiyagu M Savarimuthu Francis, Jill E Larsen, Sandra J Pavey, Edwina E Duhig, Belinda E Clarke, Rayleen V Bowman, Nick K Hayward, Kwun M Fong, Ian A Yang   +8 more
doaj   +1 more source

Using multiple ontologies to integrate complex biological data

Comparative and Functional Genomics, 2005
AbstractThe strength of the rat as a model organism lies in its utility in pharmacology, biochemistry and physiology research. Data resulting from such studies is difficult to represent in databases and the creation of user‐friendly data mining tools has proved difficult.
Shimoyama, Mary, Petri, Victoria, Pasko, Dean, Bromberg, Susan, Wu, Wenhua, Chen, Jiali, Nenasheva, Nataliya, Kwitek, Anne, Twigger, Simon, Jacob, Howard   +9 more
openaire   +2 more sources

The environment ontology: contextualising biological and biomedical entities [PDF]

Journal of Biomedical Semantics, 2013
As biological and biomedical research increasingly reference the environmental context of the biological entities under study, the need for formalisation and standardisation of environment descriptors is growing. The Environment Ontology (ENVO; http://www.environmentontology.org) is a community-led, open project which seeks to provide an ontology for ...
Pier Buttigieg, Norman Morrison, Barry Smith, Christopher J Mungall, Suzanna E Lewis   +4 more
openaire   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The BSSO Foundry: A community of practice for ontologies in the behavioural and social sciences [version 1; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
There has been a rapid expansion in the quantity and complexity of data, information and knowledge created in the behavioural and social sciences, yet the field is not advancing understanding, practice or policy to the extent that the insights warrant ...
Paulina Schenk, William R. Hogan, Robert West, Björn Gehrke, Janna Hastings, Marta M. Marques, Bruce Chorpita, Harriet M. Baird, Lisa Zhang, Thomas L. Webb, Geert Crombez, Susan Michie, Marie Johnston   +12 more
doaj   +1 more source