Results 81 to 90 of about 2,999,960 (264)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Redox regulation for sustainable water purification and risk management
Environmental Science and EcotechnologySustainable detoxification and advanced treatment of toxic organic pollutants (TOPs) in wastewater are essential for water reclamation and ecosystem security.
Ai-Jie Wang +5 more
doaj +1 more source
Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.
Journal of Lipid Research, 1990 Oxidation of low density lipoprotein (LDL) causes changes in the biological properties of LDL that may be important in atherogenesis. That LDL oxidation is accompanied by lipid peroxidation has been demonstrated, but previous analyses of the products of ...
ML Lenz +7 more
doaj +1 more source
Annual Report - Marine Biological Laboratory, 1917
, 1918 Annual report of the Marine Biological Laboratory in Woods Hole. 1917.
Marine Biological Laboratory (Woods Hole MA)
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1934
, 1935 Annual report of the Marine Biological Laboratory in Woods Hole. 1934.
Marine Biological Laboratory (Woods Hole MA)
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1929
, 1930 Annual report of the Marine Biological Laboratory in Woods Hole. 1929.
Marine Biological Laboratory (Woods Hole MA)
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source