Results 81 to 90 of about 196,073 (265)

Connectional differences between humans and macaques in the MT+ complex

iScience
Summary: MT+ is pivotal in the dorsal visual stream, encoding tool-use characteristics such as motion speed and direction. Despite its conservation between humans and monkeys, differences in MT+ spatial location and organization may lead to divergent ...
Jianxiong Ruan, Ye Yuan, Yicheng Qiao, Minghao Qiu, Xueda Dong, Yue Cui, Jianhong Wang, Ning Liu   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Soft Matter and Biological Physics [PDF]

The European Physical Journal E, 2009
Jones, R., Jülicher, F., Maret, G.
openaire   +2 more sources

A new look for the Journal of Biological Physics. [PDF]

J Biol Phys, 2020
Bahar S.
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Biological physics by high-speed atomic force microscopy. [PDF]

Philos Trans A Math Phys Eng Sci, 2020
Casuso I, Redondo-Morata L, Rico F.
europepmc   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Two-dimensional flow nanometry of biological nanoparticles for accurate determination of their size and emission intensity

Nature Communications, 2016
Size and molecular composition of biological nanoparticles dictate their function, but cannot be simultaneously determined accurately. Here, Höök and others have subjected constrained biological nanoparticles on a lipid bilayer to hydrodynamic flow to ...
Stephan Block, Björn Johansson Fast, Anders Lundgren, Vladimir P. Zhdanov, Fredrik Höök   +4 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

STUDIES OF MEDICAL AND BIOLOGICAL PHYSICS BY FACILITIES OF IСT: ANALYSIS OF EXPERIENCE

Інформаційні технології і засоби навчання, 2012
The article devoted to the problem of implementation of methodical system of medical and biological physics education by facilities of information and communication technologies.
Nataliia V. Stuchynska
doaj