Results 61 to 70 of about 196,073 (265)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiols in vivo and in vitro

iScience
Summary: Lysosomal biothiols play critical roles in numerous cellular processes and diseases. Researching an effective method for real-time labeling biothiols in lysosomes is of great significance and urgency, as it could provide essential information ...
Taotao Zhao, Tong Zhang, Zijun Tao, Zhe Zhou, Xiaofeng Xia, Zhengjun Wu, Feiyi Wang, Jun Ren, Erfei Wang   +8 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Interactions between electromagnetic radiation and biological systems

iScience
Summary: Even though the bioeffects of electromagnetic radiation (EMR) have been extensively investigated during the past several decades, our understandings of the bioeffects of EMR and the mechanisms of the interactions between the biological systems ...
Lingyu Liu, Bing Huang, Yingxian Lu, Yanyu Zhao, Xiaping Tang, Yigong Shi   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Optical modulation of cell nucleus penetration and singlet oxygen release of a switchable platinum complex

iScience
Summary: The activation of anticancer molecules with visible light constitutes an elegant strategy to target tumors and to improve the selectivity of treatments.
Zakaria Ziani, Saioa Cobo, Nathalie Berthet, Guy Royal   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

MEDICAL AND BIOLOGICAL PHYSICS AS A FUNDAMENTAL NATURAL DISCIPLINE: MODERN CHALLENGES AND INNOVATIONS IN PRE-PROFESSIONAL AND PROFESSIONAL MEDICAL EDUCATION

Клінічна та профілактична медицина
Aim. To analyze the impact of physical and technical discoveries on the development of instrumental and new, high-tech methods in medicine. To investigate modern educational processes in institutions of pre-professional and professional medical education
Olexandr V. Chalyi, Olena M. Chaika, Dmytro V. Lukomsky, Elena V. Zaitseva, Natalia L. Grytsenko   +4 more
doaj   +1 more source

Using Entropy Leads to a Better Understanding of Biological Systems

Entropy, 2010
In studying biological systems, conventional approaches based on the laws of physics almost always require introducing appropriate approximations. We argue that a comprehensive approach that integrates the laws of physics and principles of inference ...
Chih-Yuan Tseng, Jack A. Tuszynski
doaj   +1 more source