Results 51 to 60 of about 196,073 (265)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Editorial for the Special Issue “Feature Papers in Chemistry and Physics of Biological Gels”

Gels
We are excited to share with Gels’ community the Special Issue on the chemistry and physics of biological gels [...]
Esmaiel Jabbari
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Can the Brain Be Relativistic?

Frontiers in Neuroscience, 2021
Reza Rastmanesh, Reza Rastmanesh, Matti Pitkänen   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Elucidating the linagliptin and fibroblast activation protein binding mechanism through molecular dynamics and binding free energy analysis

iScience
Summary: Fibroblast activation protein (FAP) is highly expressed in solid tumors and may be a potential diagnostic and therapeutic target in solid cancers.
Mingsong Shi, Fang Wang, Zhou Lu, Yuan Yin, Xueting Zheng, Decai Wang, Xianfu Cai, Meng Jing, Jianjun Wang, Junxian Chen, Xile Jiang, Wenliang Yu, Xiaoan Li   +12 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Bio-inspiration unveiled: Dissecting nature’s designs through the lens of the female locust’s oviposition mechanism

iScience
Summary: Investigating nature’s ingenious designs and systems has become a cornerstone of innovation, influencing fields from robotics, biomechanics, and physics to material sciences.
Amir Ayali, Shai Sonnenreich, Bat El Pinchasik   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Resonance tuning of rhythmic movements is disrupted at short time scales: A centrifuge study

iScience
Summary: The human body exploits its neural mechanisms to optimize actions. Rhythmic movements are optimal when their frequency is close to the natural frequency of the system. In a pendulum, gravity modulates this spontaneous frequency.
Olivier White, Victor Dehouck, Nicolas Boulanger, Frédéric Dierick, Jan Babič, Nandu Goswami, Fabien Buisseret   +6 more
doaj   +1 more source