Results 41 to 50 of about 196,073 (265)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Inventive Activity of the Institute of Biological Physics

Informaciâ i Innovacii, 2018
The article considers its inventive activity of the Institute of Biological Physics (before and after the separation into the Institute of Theoretical and Experimental Biophysics and the Institute of Cell Biophysics).
Ivan Mitroshin, Irina Mitroshina
doaj   +1 more source

Highly efficient self-powered perovskite photodiode with an electron-blocking hole-transport NiOx layer

Scientific Reports, 2021
Hybrid organic–inorganic perovskite materials provide noteworthy compact systems that could offer ground-breaking architectures for dynamic operations and advanced engineering in high-performance energy-harvesting optoelectronic devices.
Amir Muhammad Afzal, In-Gon Bae, Yushika Aggarwal, Jaewoo Park, Hye-Ryeon Jeong, Eun Ha Choi, Byoungchoo Park   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

Nature Communications, 2023
Within the nucleus, the genome of eukaryotes folds into partially organized three-dimensional structures specific to each organism. Here the authors perform physical simulations to study the genome architecture of Aedes aegypti, which reveal an ensemble ...
Vinícius G. Contessoto, Olga Dudchenko, Erez Lieberman Aiden, Peter G. Wolynes, José N. Onuchic, Michele Di Pierro   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A física no contexto da biologia molecular

Revista Brasileira de Ensino de Física
Nas últimas décadas tem havido uma crescente abordagem física no estudo de moléculas e sistemas macromoleculares de interesse biológico. Essa abordagem inclui tanto aspectos experimentais quanto teóricos.
Elso Drigo Filho
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing the impact of introductory physics for the life sciences on students’ ability to build complex models

Physical Review Physics Education Research, 2022
A central goal of introductory physics for the life sciences (IPLS) is to prepare students to use physics to model and analyze biological situations, a skill of increasing importance for their future studies and careers.
Benjamin D. Geller, Maya Tipton, Brandon Daniel-Morales, Nikhil Tignor, Calvin White, Catherine H. Crouch   +5 more
doaj   +1 more source